超声生物力学方法评价2型糖尿病患者肱动脉生物力学特征  

Biomechanical properties of brachial artery in patients with Type 2 diabete by biomechanical ultrasound

作　　者：陈明[1] 马静[1] 金醒昉 刘怡[1] 刘超[3] 杨莉 田毅[4] 

机构地区：[1]同济大学附属东方医院心脏中心,上海200120 [2]昆明市延安医院 [3]云南省第一人民医院 [4]昆明理工大学建筑工程学院

出　　处：《中华医学超声杂志（电子版）》2008年第6期33-36,共4页Chinese Journal of Medical Ultrasound(Electronic Edition)

摘　　要：目的采用超声生物力学方法评价2型糖尿病患者肱动脉生物力学特征。方法对2型糖尿病患者和正常对照组各15例,在基础状态和舌下含服硝酸甘油后,采用血压袖带充气加压,分别在0mmHg、1/3舒张期血压(DBP)、2/3DBP、3/3DBP条件下对右肱动脉行二维超声及M型超声扫查,检测右肱动脉长轴舒张末期最大内径、血管内膜-中层厚度、血管壁厚度,通过Lange-wouters公式计算肱动脉血管面积、顺应性、应变、应力,并绘出2型糖尿病组和对照组在基础状态和含硝酸甘油后肱动脉的压力-血管面积曲线、压力-顺应性曲线及应变-应力曲线。结果2型糖尿病组硝酸甘油状态下肱动脉血管内径、血管面积、血管壁顺应性的增幅及血管壁应力的降幅均较对照组明显减小(P<0.05或0.01),应变-应力曲线明显右移。结论超声生物力学方法能够应用于评价在体肱动脉的力学性质,为糖尿病患者外周血管病变提供一种无创伤性力学分析方法。Objective By calculating the mechanical parameters noninvasively of brachial artery （BA） in patients with type 2 diabete, the mechanical properties of BA were measured in vivo. Methods A total of fifteen patients with type 2 diabete were enrolled and 15 healthy subjects were chosen as the control group. The image of BA were displayed and morphological parameters were collected by ultrasound. The mechanical data in BA were calculated using Langewouters equation. Results The increments of diameter, area, compliance and the decrements of stress of BA were decreased significantly after administration of nitroglycerine（P 〈0.05 or P 〈0.01 ）. The strain-stress curve was markedly shifted rightward in the group of patients with type 2 diabetes compared to those in the control group. Conclusions The mechanical measurements of ultrasound might be a reliable method for calculating mechanical properties of BA in vivo, which could provide a biomechanics analysis of peripheral artery in the patients with type 2 diabete noinvasively.

关 键 词：超声检查 非胰岛素依赖型糖尿病 肱动脉 生物力学 

分 类 号：R587.1[医药卫生—内分泌] R686.5[医药卫生—内科学]