性激素与人乳头瘤病毒感染的相关性分析  

Analysis on the relationship between sex hormones and human papillomavirus infection

作　　者：胡艳君[1] 王佐[1] 林晓华[1] 金鑫行[1] 

机构地区：[1]浙江省温州市妇幼保健院.浙江省温州市第三人民医院妇产科,325000

出　　处：《中国妇幼保健》2008年第35期4986-4987,共2页Maternal and Child Health Care of China

基　　金：浙江省温州市科技计划项目(Y20070160)

摘　　要：目的:对非妊娠期、妊娠各期的妇女进行血清雌二醇(E2)、孕酮(P)及宫颈分泌物HPV检测,以探讨性激素与人乳头瘤病毒感染的相关性。方法:利用酶免疫化学发光法检测120例非妊娠期、孕早期、孕中期、孕晚期的妇女血清中E2、P水平,利用DNA杂交导流技术和基因芯片技术检测其宫颈分泌物标本作HPV-DNA测定。结果:HPV感染率与血清中E2、P呈正相关。结论:雌、孕激素是HPV感染的重要协同因子。Objective： To test the levels of cstradiol （E2 ）, progesterone （P） in the serum and HPV DNA in the cervical mucus of non - pregnant and pregnant women in each stage, investigate the relationship between sex hormones and human paLlipomavirus （HPV） infecton. Methods： The levels of E2 and P in the serum were tested by ehemiluminescent enzyme immunoassay staining. The expression of HPV DNA in the cervical mucus was determined by the flow - guiding technology of DNA hybridization and the gene chip technology. Results： The infection rate of HPV was positively related to the levels of E2 and P in the serum. Conclusion： The levels of E2 and P in the serum have a significant effect on HPV infection.

关 键 词：雌二醇 孕酮 人乳头瘤病毒 

分 类 号：R373[医药卫生—病原生物学] R711[医药卫生—基础医学]