鱼类解偶联蛋白(UCP)基因研究新进展  

Recent research progress in fish uncoupling protein gene

作　　者：梁旭方[1] 王琳[1] 马旭[1] 

机构地区：[1]暨南大学生命科学技术学院,广东广州510632

出　　处：《水产学报》2008年第6期965-970,共6页Journal of Fisheries of China

基　　金：国家自然科学基金(30670367);国家"八六三"高技术研究发展计划项目(2007AA09Z437);广东省自然科学基金(031886);教育部留学国回国人员科研启动基金项目

摘　　要：The regulation of energetic efficiency through the physiological uncoupling of oxidative phosphorylation may be a common strategy developed early in evolution.Uncoupling protein families are transporters in mitochondrial inner membrane.There are five UCP homologs in mammalian genome.UCP1-3 are closely related with each other,while UCP4 and UCP5(also called brain mitochondrial carrier protein-1,BMCP1) differ from them greatly.UCP1-4 were discovered not only in endotherms such as mammals and birds,but also in ectothermic vertebrates such as fish and amphibia.UCP5 was identified only in mammals.UCP1,which is only expressed in mammalian brown adipose tissue,mediates proton leakage of the proton gradient that is generated by the respiratory chain,and as a result,the oxidative energy is dissipated as heat.UCP2 and UCP3 function both in fever,ROS inhibition,fatty acid oxidation,the development of obesity and type 2 diabetes mellitus and so on.Their expression regulations are complex.UCP4 and UCP5 diverge from other UCP further. UCP4 is uniquely expressed in brain,whilst UCP5 transcripts are present in multiple tissues,with an especially high abundance in brain.Their functions are still unclear,but they have been implicated in processes similar to those suggested for UCP2 and UCP3.The regulation of energetic efficiency through the physiological uncoupling of oxidative phosphorylation may be a common strategy developed early in evolution. Uncoupling protein families are transporters in mitochondrial inner membrane. There are five UCP homologs in mammalian genome. UCP1 - 3 are closely related with each other, while UCP4 and UCP5 （also called brain mitochondrial carrier protein- 1, BMCP1） differ from them greatly. UCP1 - 4 were discovered not only in endotherms such as mammals and birds, but also in ectothermic vertebrates such as fish and amphibia. UCP5 was identified only in mammals. UCP1, which is only expressed in mammalian brown adipose tissue, mediates proton leakage of the proton gradient that is generated by the respiratory chain, and as a result, the oxidative energy is dissipated as heat. UCP2 and UCP3 function both in fever, ROS inhibition, fatty acid oxidation, the development of obesity and type 2 diabetes mellitus and so on. Their expression regulations are complex. UCP4 and UCP5 diverge from other UCP further. UCP4 is uniquely expressed in brain, whilst UCP5 transcripts are present in multiple tissues, with an especially high abundance in brain. Their functions are still unclear, but they have been implicated in processes similar to those suggested for UCP2 and UCP3.

关 键 词：鱼类 UCP基因家族 表达调控 活性氧 细胞凋亡 脂肪酸氧化 

分 类 号：S917[农业科学—水产科学]