急性白血病患儿治疗前后细胞因子IFN-γ、IL-4的变化及意义  

Changes of serum Th1/Th2 cytokines IFN-γ and IL-4 level and clinical significance in patients with acute leukemia in children

作　　者：周海霞[1] 钱江潮[1] 江明华[2] 王菊香[1] 阮积晨[1] 李原[1] 

机构地区：[1]温州医学院附属育英儿童医院血液科,浙江温州325027 [2]温州医学院附属育英儿童医院检验科,浙江温州325027

出　　处：《温州医学院学报》2008年第6期516-519,共4页Journal of Wenzhou Medical College

基　　金：温州市科技局科研基金资助项目(Y2004A119)

摘　　要：目的:探讨急性白血病患儿Th1/Th2细胞因子IFN-γ、IL-4的变化及意义。方法:采用酶联免疫吸附试验方法(ELISA)检测了29例急性白血病患儿初发时、26例急性白血病患儿完全缓解(CR)后外周血血清IFN-γ、IL-4水平,并与同期20例正常体检儿童对照组比较。结果:急性白血病患儿初发组外周血血清IFN-γ水平较完全缓解组、对照组明显降低(P<0.01),完全缓解组IFN-γ水平回升,与对照组比较,差异无显著性(P>0.05);急性白血病患儿初发组外周血血清IL-4水平较完全缓解组、对照组明显升高(P<0.01),完全缓解组IL-4水平下降,与对照组比较,差异无显著性(P>0.05)。结论:儿童急性白血病的发病可能与Th1/Th2细胞因子失调有关,是Th2优势疾病。To investigate the expression of serum interferon-ganma （IFN-γ）, Interleukin -4 （IL-4） levels in children of acute leukemia patients （AL）. Methods： The serum levels of IFN-γ . IL- 4 were indirectly tested by enzyme-linked immunosorbentassay （ELISA） method in the untreated AL group （29 cases）, the CR （complete remission） AL group （26 cases） and the normol control group （20 cases）. Results： The serum IFN-γ levels of the untreated AL group was lower than that of the CR AL group and the normol control group （P〈0.01）, but the level of IL-4 was higher （P〈0.01）. There was no significant difference about the serum IFN-γ, IL-4 levels between the CR AL group and the normol control group （P〉0.05）. Conclusion： Our results suggest that there be an abnormal expression of cytokines and an abnormal profile of Th1/Th2 from children with AL. AL is a Th2 polarized disease. These disorders may have significant meanings in mechanism of AL.

关 键 词：白血病 Γ-干扰素 白细胞介素-4 

分 类 号：R541.9[医药卫生—心血管疾病]