附属基因调节子在葡萄球菌生物被膜形成与感染中的作用  

Accessory gene regulator in Staphylococcus biofilm formation and infection

作　　者：唐俊妮[1,2] 周锐[2] 王红宁[1] 曾志光[1] 

机构地区：[1]四川大学生命科学学院,四川大学动物疾病防控生物工程研究中心,成都610065 [2]华中农业大学动物医学院,华中农业大学农业微生物学国家重点实验室,武汉430070

出　　处：《中南大学学报（医学版）》2008年第11期1066-1070,共5页Journal of Central South University ：Medical Science

基　　金："十一五"国家科技支撑计划及子课题(2007BAD51B05;2006BAD14B05-5;2006BAK02A19)~~

摘　　要：葡萄球菌生物被膜是生物材料相关感染病理学中最重要的毒力因子,生物被膜形成是由群集感应系统调节的。葡萄球菌附属基因调节子agr作为群集感应系统具有种属特异性,在金黄色葡萄球菌和表皮葡萄球菌中控制着一系列毒素和毒力因子的表达,而且与天然免疫系统互作。新的研究进展表明附属基因调节子agr在体内感染中的作用非常微妙。这方面的进展有助于发掘新型抗菌剂和消除与装置相关的葡萄球菌生物被膜感染问题。The most important factor in the pathogenesis of biomaterial-associated Staphylococcal infections is the formation of bacterial biofilms. Biofilm formation was regulated or influenced by quorum sensing. One of the quorum sensing systems agr is genus specific which controls the expression of a series of toxins and virulence factors and the interaction with the innate immune system. New research indicates that the role of agr during infection is controversial. The research progress will play an important role in the development of novel antibacterial agents and management of device-related infection of Staphylococci.

关 键 词：AGR 生物被膜 感染 葡萄球菌 

分 类 号：R378[医药卫生—病原生物学]