聚(α-羟基酸)的表面侵蚀动力学行为  

Surface Erosion Kinetics of Poly(α-hydroxy acid)s

作　　者：曾敬[1] 康艳红[1] 赵桂贞[1] 苏桂田[1] 

机构地区：[1]沈阳师范大学化学与生命科学学院,辽宁沈阳110034

出　　处：《化工时刊》2008年第11期11-16,共6页Chemical Industry Times

基　　金：沈阳师范大学实验中心基金资助项目(SY200804)

摘　　要：可生物降解高分子材料的降解机理可以是主体降解也可以是表面侵蚀。目前的表面侵蚀研究主要集中在降解过程中材料表面的化学组成、结构信息、表面形貌的改变及对表面侵蚀过程进行定量分析等。综述了几种重要的可生物降解聚(α-羟基酸)的表面水解降解动力学及对药物控制释放行为的影响。这对于药物控制释放体系的研究及设计制备新型可生物降解高分子材料具有重大意义。Degradation of biodegradable polymers can proceed either in the bulk or at the surface of the material. The recent studies about surface erosion were focused on the surface chemical composition, the change of surface morphology and quantitative analyses on the surface erosion process. The radation kinetics of biodegradable poly（α--hydroxy acid）s and the effects on drug controlled structural information, surface hydrolytic degrelease behaviors were reviewed. It had an essential value not only for the study of drug controlled release systems but also toward the design and formulation of new biodegradable polymers.

关 键 词：聚(α-羟基酸) 药物控制释放 表面侵蚀 动力学 

分 类 号：O631.3[理学—高分子化学]