两种胰岛素强化疗法对2型糖尿病人胰岛β细胞功能的影响  

作　　者：黄如伦[1] 史治宙[1] 

机构地区：[1]广东湛江中心人民医院内分泌科,524037

出　　处：《中国社区医师（医学专业）》2008年第23期56-56,共1页

摘　　要：目的:比较胰岛素泵连续皮下输注(CSⅡ)和多次皮下注射治疗(MSⅡ)对初发2型糖尿患者胰岛β细胞功能的影响。方法:新诊断的2型糖尿病患者90例,随机分为MSⅡ组(45例)和CSⅡ组(45例)行胰岛素强化治疗2周,治疗前后行口服葡萄糖耐量试验,比较血糖、胰岛素、⊿I30/⊿G30、Homa-IR及INSAUC的变化。结果:两种强化治疗后空腹及餐后血糖明显下降(P<0.01);胰岛素水平升高(P<0.05),⊿I30/⊿G30升高(P<0.01);HomaIR降低(P<0.01),IN-SAUC升高(P<0.01),MSⅡ组更为明显。结论:短期CSⅡ强化治疗较MSⅡ改善初发2型糖尿病患者胰岛β细胞功能更明显。Objective：To investigate the effect of continuous subcutaneous insulin injection （CS Ⅱ ） and multiple subcutaneous insulin injection（ MSⅡ ）on islet cell function at the onset of type 2 diabetes. Method：90patients were randomly divided into CS Ⅱ and MS Ⅱ groups. The patients of both groups were given intensive insulin therapy keep two weeks. Resuh：A significant difference existed between the two groups： the level of fasting and postprandial plasma glucose △I30/△G30, Homa- IR and INSAUC. Conclusions： Short -term intensive insulin pump treatment can effectively restore or partly do the function of islet βcell than multiple subcutaneous insulin injection.

关 键 词：胰岛素泵 强化治疗 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌] R521.05[医药卫生—内科学]