异黄酮改构化合物F11对人乳腺癌裸鼠移植瘤的影响  

The Effect of Isoflavone Derivative F11 on Transplant Human Breast Cancer in Nude Mice

作　　者：尹姝心[1] 张丽龙[2] 常青[1] 粟永萍[2] 艾国平[2] 

机构地区：[1]第三军医大学西南医院妇产科,重庆400038 [2]第三军医大学预防医学院防原医学教研室,重庆400038

出　　处：《解放军药学学报》2008年第6期507-510,共4页Pharmaceutical Journal of Chinese People's Liberation Army

基　　金：重庆市院士基金资助项目;No.2004BC5006

摘　　要：目的研究异黄酮改构化合物F11对人乳腺癌裸鼠移植瘤影响。方法体外培养人乳腺癌MCF-7细胞,裸鼠皮下接种MCF-7细胞建立裸鼠移植瘤动物模型,用金雀异黄素(Genistein)和环磷酰胺为对照研究化合物F11在体抗MCF-7效应。结果通过裸鼠移植瘤模型检测,认为异黄酮改构化合物F11在体有显著的抗癌效应,效果优于Genistein。结论异黄酮改构化合物F11有较强的抑制肿瘤的作用,有值得进一步研究开发的潜在价值。Aim To investigate the effect of isoflavone derivave F11 on transplant breast cancer in nude mice.Methods Models were constructed through hypodermic inoculation of MCF-7 in nude mice. The anti-tumor activity of F11 was studied by comparing it to Genistein and Cytoxan. Results F11 had better performance than Genistein in anti-tumor tests on transplant tumor models in nude mice. Conclusion Isoflavone derivative F11 has better effect on tumor ceils and is of potential clinical value and worthy of further investigation.

关 键 词：异黄酮改构化合物F11 MCF-7 裸鼠 

分 类 号：R965[医药卫生—药理学]