温度/pH敏感型接枝共聚物瓜耳胶-g-异丙基丙烯酰胺水凝胶性质研究  

Study on Thermo- and pH-sensitive Hydrogels Constructed Using Block Copolymers of Poly(N-isopropylacrylamide) and Guar Gum

作　　者：郎轶咏[1] 王强[1] 戴华[1] 朱晓红[1] 李三鸣[2] 

机构地区：[1]解放军第202医院药剂科,辽宁沈阳110003 [2]沈阳药科大学药学院,辽宁沈阳110015

出　　处：《解放军药学学报》2008年第6期515-518,共4页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的研究自制接枝共聚物瓜耳胶-g-异丙基丙烯酰胺(GPNA)水凝胶的性质。方法分别考察了温度、离子强度、交联剂对凝胶的弹性、平衡溶胀度、收缩性及流变性影响。结果凝胶的弹性随交联剂含量增加减弱,随着离子强度增加增强;凝胶平衡溶胀率随着交联剂含量及离子强度增加均减小。凝胶收缩行为在相变温度上下有很大不同,当温度低于GPNA的临界溶解温度(LCST)时,凝胶内释放的水量与时间的1/2次方成正比增加;当温度高于GPNA的LCST时,开始阶段,水凝胶失水速率很慢;随着水凝胶失水过程向前推进,GPNA构象转变完成,水凝胶失水速率加快,凝胶收缩变化变成不可逆过程。氯化钠的加入使得水凝胶失水速率增加;温度低于聚合物LCST时,水凝胶流变曲线呈假塑型;温度高于聚合物LCST时,水凝胶流变曲线呈胀流型。随着交联剂的量逐渐增加,溶胶流变曲线从胀流型逐渐变为假塑型。结论GPNA凝胶的性质具有明显的温度及离子强度敏感性。Aim Thermo- and pH-sensitive hydrogels were synthesized using N-isopropylacrylamide and Guar gum （GG） and crosslinked with gluteraldehyde （GA）. The character of hydrogels was discussed in detail. Methods The effect of temperature, iron strength and crosslinker on the property of hydrogels was studied. Results Elasticity and EDS decreased with increasing amounts of NaCl and crosslinker. When the temperature was below the LCST, the release mass of water in the GPNA hydrogel increased with the time1/2; when the temperature was above the LCST, the GPNA hydrogel shrank slonsly before quicking increasing with the destruction of the structure of the hydrogel. With the increase of NaC1, the water-losing rate of GPNA hydrogel increased, and the shrinkability was strengthened, When the temperature was lower or higher than LCST, the flow of hydrogel was pseudoplastic flow or dilatant flow. With the increase of GA content, the flow of hydrogel changed from dilatant flow to pseudoplastic flow. Conclusion GPNA hydrogels are thermo-sensitivie and iron-strength sensitive.

关 键 词：温敏敏感 水凝胶 接枝共聚物 

分 类 号：R917[医药卫生—药物分析学] R943[医药卫生—药学]