超微细无定型头孢呋辛酯的制备研究  

Preparation of super-fine amorphous cefuroxime axetil

作　　者：廖勇[1] 崔文豪[1] 张军立 王文婷[1] 赵风云[1] 赵华[1] 

机构地区：[1]河北科技大学化学与制药工程学院,石家庄050018 [2]华北制药集团倍达有限公司,石家庄052165

出　　处：《中国抗生素杂志》2008年第12期761-764,共4页Chinese Journal of Antibiotics

摘　　要：目的研究制备超微细头孢呋辛酯的方法。方法以结晶型头孢呋辛1-乙酰氧基乙酯(头孢呋辛酯)为原料,以丙酮为溶剂,水作为反溶剂,采用反溶剂沉淀法制备无定型超微细头孢呋辛酯。结果在最佳实验条件下制得粒度分布均匀且平均粒径在400nm的头孢呋辛酯药物,质量符合中国药典要求,经傅里叶变换红外光谱(FT-IR)分析,在超微细化前后,头孢呋辛酯的分子结构没有发生变化;经x射线粉末衍射(XRD)分析知其结构为无定型。结论用本法制备头孢呋辛酯,原料、溶剂易得,成本低,操作简便。Objective To prepare super-fine cefuroxime axetil. Methods Amorphous cefuroxime axetil was prepared by means of acetone as solvent and water as anti-solvent. Results Under the optimal conditions, the amorphous cefuroxime axetil with the average particle size about 400nm was prepared. The FT-IR analysis revealed that there were no change of the physical and chemical characteristics after the processing procedure. And the nanoparticles was amouphous form according to the XRD analysis, which corresponded to the Chinese Pharmacopoeia. Conclusion Anti-solvent precipitation method offers a more direct and easier process to obtain super-fine amorphous powder of cefuroxime axetil.

关 键 词：头孢呋辛酯 超微细颗粒 反溶剂沉淀法 反溶剂 

分 类 号：TQ465.1[化学工程—制药化工]