缺血性脑白质病的MR扩散加权成像及波谱研究  

The Study of Leukoaraiosis with MR Diffusion-weighted Imaging and MR Spectroscopy

作　　者：张雪峰[1] 牛广明[2] 王颖[1] 

机构地区：[1]内蒙古自治区医院影像中心,内蒙古呼和浩特010017 [2]内蒙古医学院附属医院,内蒙古呼和浩特010050

出　　处：《内蒙古医学杂志》2008年第11期1302-1304,共3页Inner Mongolia Medical Journal

摘　　要：目的:通过MR扩散加权成像(DWI)及MR波谱(MRS)分析脑白质疏松症(LA)的表观扩散值(ADC)和不同代谢产物比值的变化,探讨LA中脑白质缺血过程中出现的病理、生化改变与MR功能成像改变之间的关系。方法:30例经常规MRI检查诊断为LA患者,及30例年龄相匹配正常脑白质表现的患者作为对照组,进行DWI检查,分析病变不同区域ADC值的变化,同时对LA患者进行MRS分析N-乙酰天门冬氨酸(NAA)/肌酸(Cr)、胆碱复合物(Cho)/肌酸(Cr)比值的变化,比较不同位置和不同程度病变在ADC值和代谢变化中的差异。结果:LA患者病灶区(双侧侧脑室枕角、体部旁脑白质)ADC值升高与对照组差异有显著的统计学意义(P<0.01),相应病灶区的NAA/Cr均值明显降低,Cho/Cr均值升高,与正常白质比较差异有显著统计学意义(P<0.01),而枕角的NAA/Cr均值低于体部,差异有显著统计学意义(P<0.01)。结论:磁共振功能成像能够反映脑白质疏松症发展过程中的微观结构变化和局部代谢的异常。Objective： To tudy the combined application of MR diffusion- weighted imaging （DWI）and metabolic abnormity in proton MR spectroscopy（HMRS）in patients with pathologic and biochemical changes in Leukoaraiosis（LA）. Methods： DWI and HMRS examination were performed in 30 cases with LA, comparing ADC and relative ratio values of each metabolite in different regions of lesion with normal white matter. DWI examination were performed in 30 cases of control group. To obtain ADC, NAA/Cr, Cho/Cr through Function - Tool. Results：The regions of lesion with LA showed the higher ADC values than the control group, there was significant difference form control group（P〈0.01 ）, the ratios of NAA/Cr were lower than normal white matter, and Cho/Cr were higher than normal white matter, there was significant difference with them. Conclusion： DWI and MRS reveals the changes in microcosmic structure and abnormity of focal metabolite in Leukoaraiosis.

关 键 词：脑白质疏松症 磁共振 弥散加权成像 波谱成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R742[医药卫生—诊断学]