猪脑出血血肿灶周脑白质超微结构改变  

Ultrastructures of brain white matter around hematoma with intracerebral hemorrhage in pigs

作　　者：孟祥武[1] 唐洲平[2] 唐荣华[2] 石元洪[2] 陈兴泳[2] 谢雪微[2] 胡伟[2] 李在望[2] 陈劲草[2] 

机构地区：[1]湖北民族学院附属医院,湖北恩施445000 [2]华中科技大学同济医学院临床神经研究中心

出　　处：《中华实验外科杂志》2008年第12期1635-1636,共2页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金资助项目（30570628、30770751）

摘　　要：目的观察猪脑出血后不同时间血肿灶周白质的超微结构的变化。方法选取小猪15头，随机分为实验组12头和对照组（假手术组）3头，其中实验组1、3、5、7d各3头。取血肿周围白质行超微结构观察，对照组（假手术后3d）取相对应脑白质超微结构观察。结果脑出血后1d可见胶质细胞及神经纤维较明显的结构改变；3d时病变最重；5～7d，胶质细胞及纤维损伤有所减轻。结论脑出血后宜尽早采取有效的干预措施，从始动环节上抑制或减轻继发性脑白质损伤。Objective To observe the uhrastructures of brain white matter around hematomain with intracerebral hemorrhage （ICH） in pigs. Methods Fifteen Pigs were randomly divided into two groups：control group （3 pigs） and experiment group （ 12 pigs）. Autologous blood was infused into basal ganglia in experiment pigs to observe the ultrastructure of brain white matter under an electron microscope on the postoperative day 1,3,5,7. Results Astroeyte and nerve fiber were obviously changed in ultrastructure on the first day after operation. On the third day this change presented most obviously and after 5th day this injury began to relief. Conclusion It is important to prevent brain white matter damage at early stage for ICH.

关 键 词：脑出血 超微结构 脑白质 猪 

分 类 号：S858.28[农业科学—临床兽医学]