托特罗定防治良性前列腺增生患者围手术期膀胱痉挛的临床疗效  

Tolterodine to prevent and treat bladder spasm around the operation to BPH

作　　者：陶然[1] 庞松强[1] 刘金[1] 

机构地区：[1]中国医科大学北京顺义医院泌尿外科,101300

出　　处：《中华泌尿外科杂志》2008年第12期843-845,共3页Chinese Journal of Urology

摘　　要：目的探讨良性前列腺增生（BPH）患者围手术期膀胱痉挛的有效防治方法。方法BPH患者112例，随机分为2组，每组56例。治疗组应用酒石酸托特罗定治疗，术前4～5d，术后3～4d，2mg，2次／d。对照组不服用任何对膀胱痉挛有影响的药物。观察比较2组患者经尿道前列腺切除术后膀胱痉挛发生频率、持续时间等。结果对照组56例患者麻醉效应过后未发生膀胱痉挛7例（12．5％）、轻度膀胱痉挛（偶感耻骨上膀胱区及尿道疼痛不适）8例（14．3％）、膀胱痉挛（膀胱区阵发性疼痛伴尿液自尿管周围溢出）41例（73．2％）。治疗组56例患者麻醉效应过后未发生膀胱痉挛49例（87．5％）、轻度膀胱痉挛5例（8．9％）、膀胱痉挛2例（3．6％）。2组膀胱痉挛发生率比较差异有统计学意义（P〈O．001）。2组患者均无严重不良反应发生，拔除尿管后排尿均通畅。结论BPH围手术期应用托特罗定防治膀胱痉挛，可减轻患者痛苦、防止出血和尿管堵塞，临床效果满意、安全。Objective To evaluate the efficacy of tolterodine in preventing bladder spasm during the operation to BPH. Methods One hundred and twelve cases of BPH patients were randomized to two groups： 56 cases in one group were prescribed tolterodine 4--5 d before operation and 3 4 d after operation （2 mg twice daily）, another 56 cases did not take any anti-spasm drugs. The bladder spasm occurring or not, frequency and continuing time of bladder were evaluated and recorded. Results In the controlling group： the non bladder spasm in 12.5% （7/56）, mild bladder spasm in 14. 3%（8/56）, severe bladder spasm in 73.3% （41/56）, In the treatment group： non bladder spasm in 87. 5% （49/ 56）, mild bladder spasm in 8.9% （5/56）, severe bladder spasm in 3.60/oo （2/56）. There was significant difference between the 2 groups （P〈0. 001）. Conclusion Tolterodine could alleviate bladder spasm around the operation to BPH.

关 键 词：良性前列腺增生 托特罗定 膀胱痉挛 

分 类 号：R686[医药卫生—骨科学]