3-O-甲基-4,6-O-苯亚甲基-N-(2-吡啶基)-α-D-葡萄糖的合成研究  

The Research on the Synthesis of 3-O-methyl-4,6-O-benzylidene-N-(2-pyridyl)-α-D-glucopyranosylamine

作　　者：沈超[1] 赵卿[1] 章鹏飞[1] 

机构地区：[1]杭州师范大学材料与化学化工学院,浙江杭州310036

出　　处：《杭州师范大学学报（自然科学版）》2008年第6期449-452,共4页Journal of Hangzhou Normal University(Natural Science Edition)

基　　金：浙江省自然科学基金人才(省杰出青年团队)资助项目(R406378)

摘　　要：研究了以α-D-葡萄糖为原料,经异丙叉基保护、甲基化、苯亚甲基化等步骤合成了3-O-甲基-4,6-O-苯亚甲基-N-(2-吡啶基)-α-D-葡萄糖,产物经质谱、核磁共振谱及红外光谱对其进行了结构表征分析。N-杂环取代的糖类化合物是一种重要的医药和有机合成中间体,该类化合物将在合成糖基、核苷类似物、杂环化合物、糖多肽等具有潜在药理活性的化合物中具有广阔的应用前景.The paper researches on a novel method for the synthesis of 3-O-methyl-4, 6-O-benzylidene-N-（g-pyridyl）-α-D-glucopyranosylamine by using D-glucose as the starting material through multi-step and the product is synthesized and characterized by MS, NMR, IR first time. The 3-O-methyl-4, 6-O-benzylidene-N-（2-pyridyl）-α-D-glucopyranosylamine is an important pharmaceutical and organic intermediate which could serve as versatile intermediates for the synthesis of glycosyl derivatives such as thioureas, nucleosides, heterocyclic compounds, polypeptide, etc.

关 键 词：D-葡萄糖 3-O-甲基-4 6-O-苯亚甲基-N-(2-吡啶基)-α-D-葡萄糖 医药和有机中间体 合成 

分 类 号：O621.3[理学—有机化学]