2型糖尿病患者尿单核细胞趋化蛋白-1排泄的变化及其意义  

Changes and their significance of urinary monocyte chemoattractant protein-1 excretion in type 2 diabetics

作　　者：赵俐丽[1] 叶山东[1] 郑茂[1] 钱燕[1] 姚新明[1] 徐将[1] 孙致连[1] 

机构地区：[1]安徽医科大学附属省立医院,安徽合肥230001

出　　处：《中华疾病控制杂志》2008年第6期591-593,共3页Chinese Journal of Disease Control & Prevention

基　　金：安徽省自然科学基金(01041181)

摘　　要：目的观察2型糖尿病(type 2 diabetes mellitus,T2DM)患者尿单核细胞趋化蛋白-1(MCP-1)排泄的变化并分析尿MCP-1排泄与尿白蛋白排泄的关系。方法正常对照组20例(A组),56例2型糖尿病患者据其尿白蛋白/肌酐比值(the ratio of urinary albumin to creatinine ACR:mg·g-1·Cr-1)分为正常白蛋白尿组(B组,N=21),微量白蛋白尿组(C组,N=20),临床白蛋白尿组(D组,N=17)。检测所有入选者尿MCP-1/尿肌酐(Ucr)比值及其相关因素。结果与对照组比较,B组、C组、D组在年龄、性别、体重指数方面差异无统计学意义;与A组比较,B组尿MCP-1/Ucr水平显著升高(P<0.01),C组和D组尿MCP-1/Ucr水平进一步升高(P<0.01);尿MCP-1/Ucr水平与UAlb/Ucr、HbA1c、血清TC和TG呈正相关。结论2型糖尿病患者尿MCP-1排泄增加,并与糖尿病肾病的病情程度有关。Objective To observe the changes of the urinary MCP-1 excretion, and analyse its relationship with albuminuria in T2DM. Methods 20 normal controls （group A, N = 20） and 56 diabetics were enrolled in this study, with diabetics, were divided into 3 groups according to （ACR： mg·g^-1· Cr^-1 ） ： normoalbnminuria group （group B, N = 21 ）, micro-albuminuria group （group C, N = 20）, and macroalbuminuria group （group D, N = 17）. Urinary MCP-1 were measured by enzyme-linked immunosorbent assay （ELISA）. Results There were no significant differences between normal control group and group B, C and D in age, sex, and body mass index; Compared with group A, the UMCP-1/ urinary creatinine （Ucr） in group B increased significantly （P〈0.01 ）, and increased further in group C and group D （P 〈 0.01 ）; UMCP-1/Ucr was positively related with ACR, HbAlc, serum TC and TG. Conclusions UMCP-1 excretion is increased in type 2 diabetics, which is related to the degree of dia- betic nephropathy.

关 键 词：糖尿病 2型 单核细胞化学吸引蛋白质-1 肾病 

分 类 号：R587.24[医药卫生—内分泌]