双黄痛风胶囊抗痛风性关节炎作用研究  

Effect of Shuanghuang Tongfeng Capsules on Experimental Gouty Arthritis

作　　者：张白嘉[1] 刘亚欧[1] 黄利[1] 潘嘉[1] 刘榴[1] 

机构地区：[1]四川省中药研究所,成都市610041

出　　处：《中国药房》2008年第36期2816-2817,共2页China Pharmacy

摘　　要：目的:研究双黄痛风胶囊(SHTF)抗痛风性关节炎的作用。方法:采用尿酸钠(MSU)建立大鼠及家兔痛风性关节炎模型,测定大鼠足肿胀程度,家兔关节滑膜液量、滑膜液中白细胞数及关节滑膜组织炎症病变程度,观察SHTF抗痛风性关节炎作用。结果:大鼠灌胃SHTF5、10、20g.kg-1,能显著减轻其足肿胀程度;家兔口服SHTF4、8、16g.kg-1,能显著减少其痛风性关节滑膜液量和滑膜液中白细胞数;家兔口服SHTF8、16g.kg-1,能显著减轻其关节滑膜组织炎症病变程度。结论:SHTF对MSU所致痛风性关节炎具有显著的保护作用。OBJECTIVE：To observe the effect of Shuanghuang tongfeng capsule（SHTF） on the gouty arthritis.METHODS：The gouty arthritis model of rats and rabbits were induced using sodium urate（MSU）. The swollen degree of the rat foot, and the amount of synovial fluid, the leucocyte count in synovial fluid and the degree of inflammation of the synovial tissue of joints in rabbits were measured.The effect of SHTF on gouty arthritis was observed. RESULTS： The swollen degree of the foot of rat was lessened obviously by SHTF capsule（5,10,20 g · kg^- 1,ig） .The amount of synovial fluid and the leucocyte count in synovial fluid of the rabbit were decreased significantly by SHTF capsule （4, 8, 16 g · kg^ -1, po） .The inflammation of the synovial tissue in rabbits was improved obviously by SHTF capsule （8 and 16 g · kg^-1, po） . CONCLUSION： SHTF capsule have remarkable protective effect on the gouty arthritis induced by sodium urate.

关 键 词：双黄痛风胶囊 尿酸钠 痛风性关节炎 

分 类 号：R283.65[医药卫生—中药学] R285.5[医药卫生—中医学]