艾司洛尔预防气管插管心血管反应的临床观察  

Effects of esmolol on cardiovascular responses during tracheal intubation

作　　者：刘凤娟[1] 张锐[1] 王宏伟[1] 安万丰[1] 

机构地区：[1]哈尔滨242医院,150066

出　　处：《航空航天医药》2008年第4期207-208,共2页Aerospace Medicine

摘　　要：目的:研究艾司洛尔预防气管插管心血管反应的临床效果与安全性。方法:90例病人随机分为3组,A组为对照组,B组为0.5mg/kg艾司洛尔组,C组为1mg/kg艾司洛尔组。麻醉为静注芬太尼2ug/kg,异丙酚和司可林诱导气管插管。监测诱导后、插管后1、2、3、4、5、6、7、8、9、10min时的收缩压、舒张压和心率。结果:①诱导后A、B、C三组SBP均显著下降(P<0.01),C组HR显著下降(P<0.01)。2)插管后A、B、C三组SBP分别上升31.7%(P<0.01)20.8%(P<0.01)和5.6%,A、B两组HR分别上升26.4%(P<0.01)和15%(P<0.01).但C组HR无改变。结论:艾司洛尔能有效地抑制喉镜窥视与气管插管的心血管反应,而1mg/kg的艾司洛尔可能是较安全的剂量。Objective： To investigate the effect and safety of esmolol on cardiovascular responses during laryngoscopy and tracheal intubation.Methods：90 adult ASA Ⅰ- Ⅱ patients scheduled for noncardiac surgery under general anesthesia were randomly divided into three groups.Group A received normal saline 10ml intravenously, group B esmolol 0.5mg/kg and group C esmolol lmg/kg.Anesthesia was induced with fentany 2ug/kg. propofol 1.5mg/kg and scc 1.5mg/kg, SBP, DBP and HR were recorded immediately before induction and esmolol of normal saline.before intubation and at 1,2,3,4,5,6,7,8,9 and 10min after intubation.Results： （i）SBP in all groups and HR in group C decreased significantly（ P 〈 0.01） after induction. 2 ） SBP increased by31.7 % （ P 〈 0.01）, 20.8 % （ P 〈 0.01 ） and 15 % （ P 〈 0.01）in group A and B respectively. But no change in group C after intubation. Conclusions： Esmolol can attenuate effectively the cardiovascular responses during laryngoscopy and tracheal intubatoin, and the dosage of 0.5 to 1mg/kg of the esmolol may be safety in such circumstances of anesthesia induction.

关 键 词：艾司洛尔 气管插管 心血管反应 

分 类 号：R614.2[医药卫生—麻醉学]