冠心病患者二甲基精氨酸与颈动脉内膜厚度关系的临床研究  

The Relationship Between Asymmetric Dimethylarginine and Intima-media Thickness of the Carotid Artery

作　　者：冯薇[1] 曲秀芬[1] 夏伟[1] 宋影[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院心内二科,黑龙江哈尔滨150001

出　　处：《黑龙江医学》2008年第12期888-890,共3页Heilongjiang Medical Journal

摘　　要：目的研究冠心病患者的血清非对称性二甲基精氨酸（ADMA）水平的异常变化与颈动脉内膜厚度的相关性。方法收集2006-06~12间，在我院住院病人58例，分为行冠状动脉造影组（n=29）及正常对照组（n=29）。分别测其血浆中不对称二甲基精氨酸水平、颈动脉内膜-中膜厚度。结果冠脉造影组病人不对称二甲基精氨酸水平明显高于对照组，冠脉造影组病人颈动脉内膜-中膜厚度明显高于对照组，不对称二甲基精氨酸水平与颈动脉内膜-中膜厚度呈正相关。结论提示不对称二甲基精氨酸影响颈动脉内膜-中膜厚度，可能是引起冠状动脉粥样硬化的危险因子。Objective To investigate the relationship between asymmetric dimethylarginine （ADMA） and intima - media thickness of the carotid in the patients of coronary atheroselerosis heart disease. Methods Threety - nine normal volunteers and threety - nine patients with coronary heart disease were enrolled in this study in our hospital from June to December in 2006. The levels of ADMA,infima - media thickness of the carotid artery were evaluated. Results Both of the levels ADMA and infima - media thickness of the carotid artery had a linear eorrelafivity, correlative coefticient closed to 1. Conclusion This study reveals that plasma ADMA levels which decreases intima - media thickness of the carotid may be a marker of coronary atheroscleresis heart disease.

关 键 词：二甲基精氨酸 颈动脉内膜-中膜厚度 冠心病 

分 类 号：R514.4[医药卫生—内科学]