前列腺素E_1与依那普利治疗慢性肾小球肾炎的对比观察  

The Control Study on Curative Effects of Prostaglandin E_1 and Enalapril for Chronic Glomerulonephritis

作　　者：王洪武[1] 

机构地区：[1]江苏省淮安市第二人民医院徐州医学院附属淮安医院肾内科,223002

出　　处：《医学理论与实践》2008年第12期1394-1395,1398,共3页The Journal of Medical Theory and Practice

摘　　要：目的：观察前列腺素E1（PGE1）与依那普利治疗慢性肾小球肾炎的临床疗效。方法：全部52例患者为1995-2007年在我院住院病人,其中治疗组25例,均应用前列腺素E110μg稀释后静注每天一次,连续治疗4周。对照组27例均服用依那普利5-10mg/d,连续治疗4周。观察其血压、血肌酐、尿β2-微球蛋白、血清胱抑素、尿蛋白定量、尿NAG及尿红细胞数的变化。结果：治疗组与对照组的尿蛋白定量、尿NAG较治疗前明显下降,尿红细胞数改变不明显。治疗组血肌酐、血清胱抑素均有不同程度下降,而对照组下降不明显,治疗组副作用小,而对照组副作用大。结论：前列腺素E1（PGE1）治疗慢性肾小球肾炎有较好的临床效果,且毒副作用远较依那普利为小,可作为慢性肾小球肾炎首选治疗方法之一。Objective; To observe the clinical effects of prostaglandin E： （PGE1） and enalapril in treatments of chronic glomerulonephritis. Methods： 52 chronic glomerulonephritis patients hospitalized between 1995--2007 were divided into two groups. 25 cases in treatment group were treated with PGE1 10μg iv,qd,for 4 weeks,and 27 cases in control group with Enalapril 5- 10mg/d for 4 weeks. The levels of blood pressure, blood creatine, urine β2-MG, cystatin C, urine protein, urine NAG and urine red cells count were observed. Results： The levels of urine protein and NAG decreased significantly after treatment in both groups, the urine red cells count did not change significantly. Blood creatine and cystalin C decreased at different degrees in treatment group, they hadfft significant decrease in control group. The side t fleets in control group were more than that in treatment group. Conclusions：PGE1 has better clinical effect on chronic nephrapathy than enalapril,and has little side effect. So it can be used as an important therapy for chronic glomerulonephritis.

关 键 词：前列腺素E1 慢性肾小球肾炎 依那普利 

分 类 号：R692.31[医药卫生—泌尿科学]