慢性酒精中毒患者认知功能与事件相关电位研究  

A study on cognitive function and event related potential in chronic alcoholism patients

作　　者：张静华[1] 金丽萍[2] 王婷[1] 

机构地区：[1]济宁市精神病防治院,济宁272051 [2]贵阳医学院附属医院

出　　处：《中国行为医学科学》2008年第12期1093-1094,共2页Chinese Journal of Behavioral Medical Science

摘　　要：目的探讨慢性酒精中毒患者的认知功能和事件相关电位（ERP）的变化，并评价ERP（P300）在认知功能障碍测评中的应用。方法对100例慢性酒精中毒患者和70名正常对照进行韦氏成人智力量表、韦氏记忆测验中文版测评和ERP检测。结果慢性酒精中毒患者的言语智商[（90．77±15．34）分]、操作智商[（91．72±15．30）分]、总智商[（91．05±19．73）分]、Stroop—C时间[（173．81±12．35）s]、Stroop—CW时间[（1176．21±40．92）s]、逻辑记忆测验[（10．32±3．39）s]、视觉再生测验成绩低于对照组（P〈0．05，P〈0．01）。慢性酒精中毒患者ERP的P3a、P3b波的潜伏期延长，波幅降低，与对照组比较差异有显著性（P〈0．01）。慢性酒精中毒患者智力测验的智力障碍检出率为43％，明显低于ERP的检出率56％（x^2=7．17，P〈0．01）。结论慢性酒精中毒患者的认知功能受到损害。P300变化在发现认知功能损害方面比智力测查更敏感。Objective To evaluate cognitive function of chronic alcoholism patients. Methods The Wechsler Adult Intelligence Scale-Revise in China（ WAIS-RC ） and WMS-RC, including intelligence quotient, logical Memory, visual memory and stroop test, were investigated and P300 component of auditory event-related potential （EHP,P300）,especially the subcomponents P3a and P3b were examined in 100 chronic alcoholism patients, and 70 healthy people matched in age , sex and educational level as controls. Results Compared with controls, the score of Verbal intelligence quotient （ VIQ ） , Performance intelligence quotient （ PIQ ） , Full-scale intelligence quotient （FIQ） , logical memory, visual memory （immediate and delayed ） , and stroop test were significant lower （P 〈 0.05, P 〈 0.01 ）in chronic alcoholism patients, but the latencies of P3a and P3b wave were significantly prolonged, the amplitude of P3a and P3 b wave were significantly decreased in chronic alcoholism patients. Conclusion Chronic alcoholism patients have cognitive function impairment, and P300 is a more sensitive to discover the impairment of the cognitive function.

关 键 词：慢性酒精中毒 P300电位 认知功能 

分 类 号：R595.6[医药卫生—内科学] R749.16[医药卫生—临床医学]