一种活性磷酸酯的分子内亲核取代反应动力学研究  

Kinetic study of the intramolecular nucleophilic substituent reaction of an activated phosphate ester

作　　者：封雪松[1] 谢家庆[1] 向庆华[1] 邹立科[1] 

机构地区：[1]四川理工学院化学系,四川自贡643000

出　　处：《化学研究与应用》2008年第12期1575-1579,共5页Chemical Research and Application

基　　金：国家自然科学基金(50572121)资助项目

摘　　要：合成和表征了大环过渡金属配合物NiL(L:高氯酸-5,7,7,12,14,14-六甲基-1,4,8,11-四氮杂环十四烷)。配合物NiL与表面活性剂组成的金属胶束作为模拟水解金属酶用于催化BNPP水解。提出了BNPP催化水解的机理;建立了用于计算动力学常数的动力学模型;计算了相关的动力学和热力学常数。结果表明,这种金属胶束表现出较高的催化活性;BNPP催化水解反应是分子内亲核取代反应;所提出的机理和建立的动力学模型是合理的。A macro-cychc transitional metal complex NiL （ L： 5,7,7,12, 14, 14-hexamethyl-1,4,8,11 tetraaza-cyclotetradecane perchlorie acid） was synthesized and characterized. The metallomicelle made up of macro-cyclic divalent metal complex and surfactant, as mimic hydrolytic metalloenzyme,was used in BNPP catalytic hydrolysis. The mechanism of BNPP catalytic hydrolysis was proposed. A correlative kinetic model was established, and corresponding thermodynamic and kinetic constants were calculated. The results show that the metallomicelle display higher catalytic activity and the course of the BNPP catalytic reaction is an intramolecular nucleophilic substituent reaction. The mechanism and kinetic model proposed in file paper should be reasonable.

关 键 词：金属胶束 模拟酶 磷酸酯水解 动力学 

分 类 号：O643.12[理学—物理化学]