生物检材中巴比妥类药物固相萃取及分析方法  

The method of solid phase extraction and analysis for barbitals in biological samples

作　　者：郭海荣[1] 裴茂清[1] 

机构地区：[1]广东省公安厅刑事技术中心,广州510050

出　　处：《刑事技术》2008年第6期16-18,共3页Forensic Science and Technology

摘　　要：目的建立生物检材中巴比妥类药物的提取净化和定性定量分析方法;方法应用固相萃取法提取生物检材中巴比妥类药物,比较了巴比妥类药物固相萃取的最佳pH值、固相吸附柱等提取条件;结果确定了巴比妥类药物的GC/NPD线性范围和GC/MS检出限;结论该方法实用,提取率高,杂质干扰少,为实际案件中巴比妥类药物的提取净化和定性定量分析提供了方法和依据。Objective To establish a qualitative and quantitative method for analysis of the barbitals in biological samples. Methods Blood samples were extracted by SPE and analyzed by GC/MS. Result The linear range of GC/NPI） and the detection limit of GC/MS are obtained. Conclusion The described method was proved to be sensitive and accurate; it can be used in determination of the barbitals in biological samples.

关 键 词：巴比妥 异戊巴比妥 戊巴比妥 苯巴比妥 固相萃取 

分 类 号：DF795.1[医药卫生—法医学]