肝前型门静脉高压兔门脉系统血管应力的研究  

Stresses in Portal Venous System of Pre-hepatic Portal Hypertension(PHT) Rabbits

作　　者：张宗棨[1] 汤松伟[1] 朱樑[1] 吴国强[2] 姜宗来[3] 施斌[1] 

机构地区：[1]第二军医大学长征医院消化内科,上海200003 [2]复旦大学力学与工程科学系,上海200433 [3]上海交通大学医学院生物力学实验室,上海200030

出　　处：《生物医学工程学杂志》2008年第6期1322-1326,共5页Journal of Biomedical Engineering

基　　金：第二军医大学青年启动基金资助项目(05QN36)

摘　　要：门脉高压症是肝硬化常见的病理生理改变。本研究采用两步门静脉结扎法制备门脉高压症(PHT)兔模型;检测不同时间点门静脉及小肠系膜曲张静脉的直径,不同程度曲张静脉及门静脉主干的血流动力学和应力(压力、剪应力和周向应力)大小。随着小肠系膜曲张静脉直径的增大,PHT兔门脉与小肠系膜静脉压力显著增加,剪应力减小,周向应力增大;两部位间应力(压力、剪应力和周向应力)呈直线正相关。研究表明,门脉高压时门脉系统处于低剪应力与高周向应力状态,这可能是门脉高压症并发症发生的力学基础。Portal hypertension is a common physiopathotogical change in liver cirrhosis. In this study, rabbits were used and the model of pre-hepatie portal hypertension （PHT） was induced by partial ligation of portal vein in two steps. We measured the diameters of portal vein and small mesenteric vein at different time-points. Then we detected the stress forces induced by blood flow in varicose veins and in portal vein; such forces included hydrostatic pressure, shear stress and circumferential stress. With the increase of the diameter of varicose small mesenterie vein, the hydrostatic pressure and circumferential stress gradually elevated and shear stress descended markedly in both the portal vein and the small mesenterie vein of PHT rabbits, between which there was a positive linear correlation. The findings in our study indicate that the complications of PHT are partially attributable to the environment of lower shear stress and higher circumferential stress in which the blood vessels of portal venous system live.

关 键 词：门静脉高压症 压力 剪应力 周向应力 门静脉高压兔 

分 类 号：R318.01[医药卫生—生物医学工程]