9-硝基喜树碱纳米胶束的制备及体外释药研究  

Investigations on Preparation and Release Behavior in Vitro of 9-Nitro Camptothecin Encapsulated Micelles

作　　者：高界铭[1,2] 明静[3] 顾忠伟[2] 张兴栋[2] 

机构地区：[1]西南交通大学材料科学与工程学院,成都610031 [2]四川大学国家生物医学材料工程技术研究中心,成都610064 [3]四川省肿瘤医院药剂科,成都610041

出　　处：《生物医学工程学杂志》2008年第6期1338-1343,共6页Journal of Biomedical Engineering

基　　金：国家973资助项目(2005CB623903)

摘　　要：利用溶剂挥发成膜法制备了负载9-硝基喜树碱（9-NC）的两亲性共聚物载药胶束。通过对制备温度、加入蒸馏水体积、搅拌速率和投药量的单因素分析，深入探讨了各因素对胶束粒径和载药量的影响。结果表明在水浴温度为60℃、加入蒸馏水体积为16ml、搅拌速率为6500r／min、投药量为1．2mg时制备得到具有良好分散状态的球状载药胶束，载药量为4．9％，粒径为50～70nm。载药胶束的体外释放研究表明，9-NC从胶束中释放包括初期爆释和随后缓释两个阶段，释放速率随载药量的增加而降低。9-nitro camptothecin （9-NC） loaded amphiphilic copolymer micelles were prepared with solvent evaporation method. The effects of temperature, distilled water volume, stirring rate, and drag input amount on the size and drug content of micelles were further discussed. As a result, well dispersed spherical micelles with drug content of 4.9 percent and 50--70 nanometers in diameter were achieved with the following preparation conditions： water bath temperature 60℃, distilled water amount 16 ml, stirring rate 6 500 r/min, and drug input amount 1.2 rag. 9-NC release profiles in vitro illustrated that drug rdease from micelles included initial burst release and following controlled release. The release rate was decreased with the increase of drug content.

关 键 词：胶束 载药量 粒径 缓释 9-硝基喜树碱 

分 类 号：TQ460.6[化学工程—制药化工]