气管组织工程的研究策略及其展望  

Current Studies and Prospective Strategies in Tissue-engineered Trachea

作　　者：史宏灿 徐志飞[2] 

机构地区：[1]扬州大学临床医学院胸心外科,扬州225001 [2]第二军医大学长征医院胸心外科,上海200003

出　　处：《生物医学工程学杂志》2008年第6期1450-1453,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(30672080);江苏省卫生厅医学重大科研项目资助(k200410);江苏省教育厅高校自然科学基金资助项目(04KJB320163)

摘　　要：气管组织工程是近10年来国内外研究的热点和难点问题,取得了一些进展。但如何更好地遴选基质材料、实现种子细胞共培养、上皮化以及再血管化来构建组织工程化气管仍需要不断寻求新的研究思路和策略。本文从气管重建和理想化气管替代物的角度,回顾了近年来在组织工程气管方面的研究进展,并对未来的研究作出展望。Over the past 10 years, much progress in the development of tracheal substitute by using tissue engineering techniques has been made. Nevertheless, some issues such as optimal extracellular matrix, cell culturing and seeding, epithelial regeneration, and revascularization remain the most stimulating challenges in tissue engineering science. It is stated that new study strategies and approaches should be explored to tackle these key problems in the near future. Here we present a review in the attempts to summarize the current advances in tissue-engineered trachea, and to look forward the prospects.

关 键 词：组织工程 气管替代物 气管重建 

分 类 号：R318[医药卫生—生物医学工程]