头颈部放疗诱发颌骨恶性肿瘤六例临床分析  

Radiation-induced maxillary malignancies： complications of radiotherapy treatment for head-neck malignant tumors

作　　者：王剑宁[1] 李汝瑶[2] 崔敏毅[3] 

机构地区：[1]中山大学光华口腔医学院口腔颌面外科,广州510055 [2]中山大学光华口腔医学院病理科 ,广州510055 [3]中山大学光华口腔医学院放射科 ,广州510055

出　　处：《中华口腔医学杂志》2008年第12期713-715,共3页Chinese Journal of Stomatology

摘　　要：目的回顾性分析头颈部放疗诱发颌面部恶性肿瘤的发病状况及表现。方法临床分析273例曾接受头颈部放疗导致放射性颌骨坏死（osteoradionecrosis，ORN）的患者中，发现6例发生颌骨恶性肿瘤，〈30岁1例，≥30岁4例，I〉60岁1例。分析273例ORN发生在放疗后的时间、患者的年龄、性别分布。结果3个年龄组放疗后诱发颌骨恶性肿瘤的构成比（单纯ORN与诱发颌骨恶性肿瘤之比为276：6）、发病年限（≤5年3例、≤10年1例、〉10年2例）、性别（男女之比为3：3）比较后，差异无统计学意义。结论放疗诱发颌骨恶性病变多位于上颌，主要表现为上颌窦高分化鳞状细胞癌或上颌骨骨肉瘤。上颌窦癌发生隐蔽，易误诊，而上颌骨骨肉瘤增长迅速。Objective To investigate the incidence of radiation-induced maxillary malignancy after radiotherapy for head and neck cancer. Methods A total of 273 patients who suffered from osteoradionecrosis after radiotherapy for head and neck cancer were evaluated. Among them, 6 patients were presented with carcinoma and sarcoma arising from maxillary area after radiotherapy. Results Radiation- induced maxillary cancers happened at a rate of 2. 2% in the patients with osteoradionecrosis. There were no statistically significant differences in age, sex and the time interval between the radiotherapy and the cancer occurence. Conclusions Radiation-induced malignancy after radiotherapy for head and neck cancer is mainly located in maxilla, presenting as squamous cell carcinoma or sarcoma of the maxillary sinus.

关 键 词：骨坏死 骨肉瘤 头颈部肿瘤 

分 类 号：R686[医药卫生—骨科学]