有效成分组替代舒胸片原复方可行性的药效学探讨  

Pharmacological study on the substitution of effective compounds group for Shuxiong Tablet

作　　者：魏巍[1] 傅继华[1] 张拓[1] 马坚[1] 戚建平[1] 平其能[1] 

机构地区：[1]中国药科大学,江苏南京210009

出　　处：《中成药》2008年第12期1748-1753,共6页Chinese Traditional Patent Medicine

基　　金：国家自然科学基金重点项目:中药复方制剂中有效成分的肠吸收机制及其口服剂型方案的研究(30430790)

摘　　要：目的:"在中药复方有效成分组"概念的指导下,比较舒胸片(三七、红花、川芎)及其有效成分组(SECG)在抗炎、镇痛、抗凝血、抗血栓和心肌保护方面的差异。方法:通过小鼠角叉菜胶足跖肿胀试验观察其抗炎作用,热水缩尾试验观察其镇痛作用,小鼠凝血试验观察其对凝血时间的影响,大鼠动静脉旁路血栓试验观察其抗血栓作用,垂体后叶素致大鼠心肌缺血试验观察其心肌保护作用。结果:舒胸片和SECG均能降低角叉菜胶导致的小鼠足跖的肿胀度,降低小鼠足局部炎症组织中前列腺素-2(PGE2)含量,增加超氧化物歧化酶(SOD)活性;提高痛阈;延长凝血时间;抑制血栓生成;抑制心肌缺血,使心肌组织中肌酸激酶(CK),乳酸脱氢酶(LDH),脂质过氧化产物丙二醛(MDA)含量明显降低,SOD活性明显升高。并且舒胸片、SECG两种组方作用一致。结论:舒胸片和SECG在抗炎、镇痛、抗凝血、抗血栓和心肌保护方面的作用效果一致,且量效关系也一致,说明SECG是舒胸片的起效成分,SECG可以替代舒胸片应用于研究及临床。AIM： To compare the difference between Shuxiong Tablet （Radix et Rhizoma notoginseng, Flos Carthami, Rhizoma Chuanxiong） （SXT） and its effective compounds group （SECG） in anti-inflammatory, relieving pain, anticoagulation, anti-thrombus and myocardial protection. METHODS ： We adopted experiments of carrageenan-induced paw edema, hot water shrink trail, clotting time in mice, and thrombus in arteriovenous shut, and pituitrin induced acute myocardial ischemia in rats. RESULTS： Both of SXT and SECG could inhibit the tumefaction, decrease PGE2 and SOD in inflammatory tissue; enhance the pain threshhold of mice; extend clotting time; inhibit the thrombosis; inhibit myocardial ischemia, significantly decrease CK, LDH, MDA and increase SOD in myocardial tissue. CONCLUSION： SXT and SECG have the same effects on anti-inflammatory, relieving pain, anticoagulation, anti-thrombus and myocardial protection. Further more, their dose-response relationship curves were similar, suggesting that SECG having the main effective components of SXT, could take place of SXT in clinical research.

关 键 词：舒胸片 有效成分组 药理学作用 小鼠 大鼠 

分 类 号：R285.6[医药卫生—中药学]