布美他尼在玻碳电极上伏安行为的研究  

Study on the Voltammetric Behaviour of Bumetanide with Glassy Carbon Electrode

作　　者：郑丽辉[1,2] 宋子旺[1,2] 郑新宇[1,3] 张兰[1,2] 

机构地区：[1]福州大学食品安全分析和检测教育部重点实验室,福州350002 [2]福州大学运动科学研究中心,福州350002 [3]福建农林大学生命科学学院,福州350002

出　　处：《分析科学学报》2008年第6期689-692,共4页Journal of Analytical Science

基　　金：福建省体育局重大专项项目(HX2005-74);福建省科技厅国际合作重点项目(No.2007I0020);福建省自然科学基金(No.B0510006;2007J0219);福建省高校新世纪优秀人才支持计划项目(HX2006-101)

摘　　要：用微分脉冲伏安（DPV）法研究了利尿剂类药物布美他尼在玻碳电极上的电化学行为。在pH2.87的B-R缓冲液中，布美他尼在＋0.896V（vs.SCE）电位处产生一个阳极氧化峰，其峰电流与布美他尼的浓度在6.0×10^-8—2.5×10^-5mol／L的范围内呈良好的线性关系，检出限（3σ／K）为2.4×10^-8mol／L。将该法应用于布美他尼实际药片及模拟尿样的测定，结果令人满意。初步探讨了布美他尼的电化学机理。The electrochemical behavior of bumetanide was studied by differential pulse voltammetry （DPV） method. The differential pules voltammograms exhibited an oxidation current peak of bumetanide at the potential of ＋0.896V （vs. SCE） in pH 2.87 Britton-Robinson （B-R） buffer solution. The peak current was linearly increased with the concentration of bumetanide over the range of 6.0×10^-8-2.5×10^-5mol/L. The detection limit of bumetanide was 2.4×10^-8mol/L. The method was applied to the assay of bumetanide in imitative human urine and bumetanide tablet with satisfactory results. A preliminary study has also been performed on the possible mechanism of bumetanid electrochemical oxidation.

关 键 词：布美他尼 玻碳电极 微分脉冲伏安法 反应机理 

分 类 号：O657.15[理学—分析化学]