盐酸倍他司汀对鲁米诺-高碘酸钾体系后发光作用机理的探讨及其快速测定  

Study of the Reaction Mechanism of Post Chemiluminescence and Determination of Betahistine Hydrochloride Reacting in the System of Luminol-KIO_4

作　　者：李德英[1] 汪芸[2] 汪敬武[1] 

机构地区：[1]南昌大学化学系,江西南昌330031 [2]广东省药品检验所,广州510180

出　　处：《分析科学学报》2008年第6期697-700,共4页Journal of Analytical Science

摘　　要：实验发现盐酸倍他司汀对鲁米诺-高碘酸钾发光体系具有后化学发光作用，并对其作用机理进行了探讨。结合流动注射技术，优化了反应条件，并建立了测定盐酸倍他司汀的新方法。该方法简便、快速、准确，线性范围为2.0×10^-7－4.0×10^-4mol／L（r=0.9975），检出限为1.0×10^-7mol／L；对4.0×10^-5mol／L的盐酸倍他司汀进行了11次平行测定，相对标准偏差为2.9％。方法成功地用于盐酸倍他司汀片中盐酸倍他司汀的测定。A post chemiluminescence phenomenon was observed when betahistine hydrochloride solution was injected into the CL reaction solution of alkaline luminal and potassium periodate. A possible reaction mechanism was proposed. Using the post chemiluminescence reaction, a new method for the determination of betahistine hydrochloride was established by flow injection. The linear response range of this method was 2.0×10^-7-4.0×10^-4mol/L with a linear correlation coefficient of 0.9975. The limit of detection was 1.0×10^7 mol/L . The relative standard deviation for 4.0×10^-5 mol/L solution was 2.90%（n= 11）. This method has been successfully applied to the determination of betahistine hydrochloride in a medicament.

关 键 词：流动注射 后化学发光 盐酸倍他司汀 

分 类 号：O657.39[理学—分析化学]