血红蛋白直接电化学的界面设计与传感研究进展  

Direct Electrochemistry of Hemoglobin:Recent Progress on Interface Designing and Biosensing

作　　者：许艳霞[1,2] 胡成国[1] 胡胜水[1,2] 

机构地区：[1]武汉大学化学与分子科学学院,湖北武汉430072 [2]传感技术国家重点实验室,北京100080

出　　处：《分析科学学报》2008年第6期705-712,共8页Journal of Analytical Science

基　　金：国家自然科学基金(No.30376397,30770549,20805035,90817103)

摘　　要：血红蛋白为人体红细胞中的一种主要蛋白质,是血液中运输氧气的主要物质。由于其类酶的性质、确定的结构以及分布的广泛性,长期以来一直是氧化还原蛋白质直接电化学以及生物传感研究的理想模型。近年来,受益于材料科学与信息技术的快速发展,血红蛋白直接电化学的界面设计以及生物传感已成为当前的研究热点。为此,本文对近年来这方面的研究进展进行综述。通过介绍血红蛋白直接电化学界面设计的基本方法以及生物传感的原理和研究现状,以探索今后的发展趋势。As the main protein in red blood cells of human, hemoglobin is the basic substance that transports oxygen in blood. It is widely used as a model to study the direct electrochemistry and biosensing of redox proteins because of its similar properties as enzymes, known and documented structure, and commercial availability. Recently, the studies on direct electrochemistry of hemoglobin on interface designing and biosensing have received great attention from scientists and become a hot field benefited from the development of material science and information technology. Therefore, the recent advances in this field are reviewed in this paper. Further research areas are suggested by the description of the basic methods in interface designing for direct electrochemistry of hemoglobin and by the principle and recent studies on biosensing.

关 键 词：氧化还原蛋白质 血红蛋白 直接电化学 生物传感器 界面设计 

分 类 号：O657.1[理学—分析化学]