Chemo- and regioselective hydroboration of Δ^(14,15) in certain cephalostatin analogue  

作　　者：Mansour Nawasreh 

机构地区：[1]Basic Sciences Department,Faculty of Engineering Technology,AI-Balqa Applied University,P.B.15008,Marka,11134 Amman,Jordan

出　　处：《Chinese Chemical Letters》2008年第12期1391-1394,共4页中国化学快报（英文版）

摘　　要：The symmetrical diketone Ⅱ, which can be synthesized in gram scale using a well established method, was used as a starting material to prepare the 11α-methoxy ketomethylene Ⅵ. This is in continuation of our study aiming at the synthesis of multihydroxylated cephalostatin analogues, as for example cephalostatin 1Ⅰ, a potent anti-tumor natural product. Compound Ⅵ underwent chemo- and regioselective hydroboration reaction at only one of △14.15 double bonds furnishing compound Ⅸ as a major product in a fair yield.The symmetrical diketone Ⅱ, which can be synthesized in gram scale using a well established method, was used as a starting material to prepare the 11α-methoxy ketomethylene Ⅵ. This is in continuation of our study aiming at the synthesis of multihydroxylated cephalostatin analogues, as for example cephalostatin 1Ⅰ, a potent anti-tumor natural product. Compound Ⅵ underwent chemo- and regioselective hydroboration reaction at only one of △14.15 double bonds furnishing compound Ⅸ as a major product in a fair yield.

关 键 词：Cephalostatin 1 DIKETONE Hydroboration of △^14 15 double bond Anti-cancer activity 

分 类 号：O621.2[理学—有机化学]