Synthesis of some new N,N'-diarylsubstituted methylene-bis-dihydro-2H-1,3-benzoxazines  

作　　者：Cherkupally Sanjeeva Reddy Mekala Raghu 

机构地区：[1]Department of Chemistry,Kakatiya University,Warangal 506009,India

出　　处：《Chinese Chemical Letters》2008年第12期1407-1410,共4页中国化学快报（英文版）

摘　　要：The synthesis of a new series of six-membered N,N′-diarylsubstituted methylene-bis-dihydro-2H-1,3-benzoxazines （5a-e） was achieved in excellent yields by Mannich-type condensation of N,N′-diarylsubstituted methylene-bis-o-hydroxybenzyl amines （4a- e） with formaldehyde in chloroform at reflux. These amines （4a-e） were obtained by the reduction of N, Nr-diarylsubstituted methylene-bis-o-hydroxybenzyl imines （3a-e） with NaBH4, which inturn were obtained by the condensation of methylene-bissalicylaldehyde （2） with various substituted arylamines.The synthesis of a new series of six-membered N,N′-diarylsubstituted methylene-bis-dihydro-2H-1,3-benzoxazines （5a-e） was achieved in excellent yields by Mannich-type condensation of N,N′-diarylsubstituted methylene-bis-o-hydroxybenzyl amines （4a- e） with formaldehyde in chloroform at reflux. These amines （4a-e） were obtained by the reduction of N, Nr-diarylsubstituted methylene-bis-o-hydroxybenzyl imines （3a-e） with NaBH4, which inturn were obtained by the condensation of methylene-bissalicylaldehyde （2） with various substituted arylamines.

关 键 词：Methylene-bis-salicylaldehyde Marmich-type condensation Methylene-bis-1 3-benzoxazines 

分 类 号：O626[理学—有机化学]