Expeditious method for the synthesis of novel 2,3,5,6-tetrahydrobenzo[g] [1,3,5]oxadiazocine-4-thiones linked with isoxazole  

作　　者：E.Rajanarendar A.Siva Rami Reddy M.Srinivas 

机构地区：[1]Department of Chemistry,Kakatiya University,Warangal 506009,India

出　　处：《Chinese Chemical Letters》2008年第12期1415-1418,共4页中国化学快报（英文版）

摘　　要：Synthesis of novel 3-aryl-5-（3,5-dimethylisoxazol-4-yl）-2,3,5,6-tetrahydrobenzo[g][1,3,5],oxadiazocine-4-thiones 5 has been accomplished from 3,5-dimethylisoxazol-4-amine 1 by condensation with salicylaldehydes, followed by reduction, treatment with aryl isothiocyanates and subsequent smooth ring closure via acetal formation in the presence of formaldehyde.Synthesis of novel 3-aryl-5-（3,5-dimethylisoxazol-4-yl）-2,3,5,6-tetrahydrobenzo[g][1,3,5],oxadiazocine-4-thiones 5 has been accomplished from 3,5-dimethylisoxazol-4-amine 1 by condensation with salicylaldehydes, followed by reduction, treatment with aryl isothiocyanates and subsequent smooth ring closure via acetal formation in the presence of formaldehyde.

关 键 词：Isoxazolyl-2 3 5 6-tetrahydrobenzo[g][1 3 5]oxadiazocine-4-thiones Ring closure New methodology 

分 类 号：O626[理学—有机化学]