Design,synthesis and characterization of a novel pH-sensitive hydrogel  

作　　者：Jiao Xia Sun Yan Feng Luo Hui Peng Zhi Wei Han 

机构地区：[1]College of Chemistry ＆ Chemical Engineering, Chongqing University, Chongqing 400030, China [2]College of Bioengineering, Chongqing University, Chongqing 400030, China

出　　处：《Chinese Chemical Letters》2008年第12期1475-1478,共4页中国化学快报（英文版）

基　　金：supported by Natural Science Foundation of Chongqing (No.CSTC2006BB5010);the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry (No.2007-1108).

摘　　要：A novel degradable pH-sensitive hydrogel with pendent carboxyl groups was designed and synthesized from ethylenediaminetetraacetic dianhydride （EDTAh） and butanediamine （BDA） with dicyclohexylcarbodiimide （DCC） as a condensating agent and BDA as a crosslinking agent. The obtained polymers were characterized by ^13C NMR, ^1H NMR and FTIR. The swelling experiments of the hydrogel in pH 3, 7, and 12 media indicated much higher swelling ratio in pH 12 media than in pH 3 and pH 7 media, exhibiting sound pH sensitivity. The pH sensitivity of this type of hydrogel may be regulated through controlling the type and the dose of the crosslinking agent.A novel degradable pH-sensitive hydrogel with pendent carboxyl groups was designed and synthesized from ethylenediaminetetraacetic dianhydride （EDTAh） and butanediamine （BDA） with dicyclohexylcarbodiimide （DCC） as a condensating agent and BDA as a crosslinking agent. The obtained polymers were characterized by ^13C NMR, ^1H NMR and FTIR. The swelling experiments of the hydrogel in pH 3, 7, and 12 media indicated much higher swelling ratio in pH 12 media than in pH 3 and pH 7 media, exhibiting sound pH sensitivity. The pH sensitivity of this type of hydrogel may be regulated through controlling the type and the dose of the crosslinking agent.

关 键 词：pH-sensitive hydrogel Ethylenediaminetetraacetic dianhydride Butanediamine 

分 类 号：TQ2[化学工程—有机化工]