基于压电基因传感器的DNA计算(英文)  

DNA Computation Based on Piezoelectric Genosensor

作　　者：方刚[1] 张运良[1] 朱岩[1] 许进[2] 

机构地区：[1]西安文理学院生命科学系,西安710065 [2]北京大学信息科学技术学院,北京100871

出　　处：《计算机学报》2008年第12期2109-2115,共7页Chinese Journal of Computers

基　　金：国家自然科学基金(60533010,60274026,30570431)资助

摘　　要：压电基因传感器是一种新型的生物传感器,它把压电传感器的灵敏性和DNA杂交反应相结合.与传统的基因检测技术相比,它具有结构简单、无需标记、检测时间短、检测信号易处理等特点.将它用于分子运算,与常规的DNA芯片相比,它的检测结果更易于进行自动化处理,因此便于构建大规模的分子运算机器.文中在压电基因传感器和新兴学科DNA计算的基础上,给出了解决0-1规划问题新的DNA计算方法,并指出以前两种基于表面DNA计算在解决这一问题时的不足.与以往的DNA计算方法相比其输出的是电信号,因此具有操作易自动化、识别解更方便和高信息量的优点.与使用常规DNA芯片的表面DNA计算相比,使用压电基因传感器进行DNA计算可以克服可行解识别困难的问题.压电基因传感器技术有望成为新的分子运算工具,可作为构建自动化的DNA计算机的基础.Piezoelectric genosensor is a new type of biosensor, which combines the sensitivity of piezoelectric sensor and DNA hybridization reaction. Compared with traditional gene assay technology, it has the simple construction, label-free feature, time-saving detection speed, and conveniently processed information. When used in DNA computing, compared with conventional DNA chip, its information is easier to process automatically. Thus it can be used conveniently to construct an automatic computing machine. Based on the piezoelectric genosensor and DNA computing theory, a new DNA computing method to solve 0-1 programming problem is proposed in this paper. Compared with other DNA computing methods, it has more significant advantages due to its electric signal output, such as massive parallel of obtaining and managing information, automatically processed signal, and label-free solution detection, etc. It also can overcome some problems, such as solution distinguishing, when carrying out DNA computing with conventional DNA chip. The piezoelectric genosensor can be used as a potential DNA computing chip to construct a DNA computer.

关 键 词：压电基因传感器 DNA芯片 DNA计算 0-1规划问题 DNA计算机 

分 类 号：TP301[自动化与计算机技术—计算机系统结构]