ADP脱敏对兔血小板ADP受体调节的影响  

Effect of ADP Desensitization on ADP Receptor Regulation of Rabbit Platelets

作　　者：葛韵琴[1] 程时[1] 李长玲[2] 李方都[3] 马健[2] 武德柱[4] 

机构地区：[1]北京医科大学生物物理教研室 [2]北京医科大学生化药理研究室 [3]蚌埠铁路医院 [4]中国原子能科学研究院

出　　处：《基础医学与临床》1990年第1期36-40,共5页Basic and Clinical Medicine

基　　金：国家自然科学基金

摘　　要：用ADP引起兔血小板脱敏,测定血小板上ADP受体的K_D及数目,并与正常血小板上的数据比较。正常血小板的K^D=0.0129nM,受体数=857.69;而脱敏血小扳的K′_D=0.0265nM,受体数=294.78。以上结果说明由于细胞表面受体的内化,使受体亲和力及受体数目减少。By using ADP desensitized rabbit platelets, the determination of KD and ADP receptor numbers in desensitized platelets were investigated, and compared with that of normal ones. In normal platelets, KD = 0.0129nM, number of receptors = 857.69; while in desensitized platelets, KD = 0.0265 nM, number of receptors= 294.78. these results indicate that desensitization leads to a reduction in receptor affinity and receptor number due to interaalization of cell surface receptors.

关 键 词：脱敏 ADP 受体 血小板聚集 调节 

分 类 号：R331.143[医药卫生—人体生理学]