加巴喷丁用于预防尿管相关性膀胱不适的有效性评估：前瞻、随机、安慰剂对照的双盲研究  

作　　者：Anil Agarwal, MD Sanjay Dhiraaj, MD Sandeep Pawar, MD Rakesh Kapoor,McH Devendra Gupta, MD Prabhat K. Singh, MD 周全红(译) 江伟(校) 

机构地区：[1]Departments of Anesthesia and Surgical Urology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India [2]不详

出　　处：《麻醉与镇痛》2008年第6期60-63,共4页Anesthesia & Analgesia

摘　　要：背景导尿管引起的尿管相关性膀胱不适（CRBD）令人痛苦。本研究评估了加巴喷丁用于预防CRBD的有效性。方法108例行择期经皮肾切开取石术的成年患者，ASAI～Ⅱ级，男女不限，随机分为2组，每组54例患者。对照组用安慰剂，G组用加巴喷丁600mg。2组患者均在手术前1小时口服药物。患者在麻醉诱导后将16F的Foley导尿管插入膀胱，气囊注入生理盐水10ml。手术后患者进入麻醉恢复室，分别在到达恢复室（0小时）、1、2和6小时的时间点评估CRBD的发生率与严重程度（轻、中、重度）。结果对照组CRBD的发生率达80％（43／54），而加巴喷丁组CRBD的发生率降低到50％（27／54）（P〈0．05）。加巴喷丁还可减轻CRBD的严重程度和手术后疼痛程度，该组手术后需要芬太尼镇痛的人数和芬太尼使用的总量都减少（P〈0．05）。结论手术前1小时口服加巴喷丁（600mg）可以减少CRBD的发生率和严重程度，减少手术后疼痛，使手术后需要芬太尼镇痛的患者例数和芬太尼需求量明显减少。BACKGROUND：Catheter-related bladder discomfort （CRBD） secondary to catheterization of urinary bladder is distressing. In the present study, we evaluated gabapentin for preventing CRBD. METHODS： One-hundred and eight consecutive adult patients, ASA physical status I and II, of either sex, undergoing elective peroataneous nephrolithotomy were randomized into two groups of 54 each. Group control： placebo and group G gabapentin： gabapentin 600 mg. Drugs were administered orally 1 h be- fore surgery. After induction of anesthesia, patients were catheterized with a 16F Foley catheter and the balloon was inflated with 10 ml normal saline. In the postanesthesia care unit, the incidence and severity （mild, moderate, and severe） of CRBD were assessed on arrival （0） and at 1,2, and 6 h. RESULTS： Gabapentin reduced the inddence of CRBD to 50% （27 of 54） compared with 80% （43 of 54） observed in the control group （P〈0.05）. Gabapentin also reduced the severity of CRBD and postoperative pain as observed by a reduction in the number of patients requiring any fentanyl and the total fentanyl consumption postoperatively （P〉0.05）. CONCLUSION： Gabapentin （600 mg） administered orally 1 h before surgery reduced the incidence and severity of CRBD, postoperative pain, number of patients requiring fentanyl and postoperative total fentanyl requirement.

关 键 词：FOLEY导尿管 加巴喷丁 安慰剂对照 插入膀胱 有效性 评估 双盲研究 不适 

分 类 号：R472.92[医药卫生—护理学] R971.6[医药卫生—临床医学]