654-2对家兔红细胞膜Na^+-K^+-ATPase活性及血浆LPO含量的影响  

Effect of 654-2 on Erythrocyte Membrane Na^+-K^+-ATPase Activity and Plasma LPO Level in Rabbit

作　　者：洪方耀 蓝庆荣 

机构地区：[1]宁波市第一医院 [2]浙江省医药学校

出　　处：《基础医学与临床》1990年第4期44-46,共3页Basic and Clinical Medicine

摘　　要：日本大耳兔9只,其中6～8月龄5只,2～2.5年龄4只。均喂以2％654-2溶液1ml/天(即20mg)共43天。结果不分年龄统计,LPO含最下降0.827±1.048 nmol/ml(P<0.05)。Na^+-K^+-ATPase活性增加0.057±0.074μmol Pi/mg pro/hr(P<0.05)。认为654-2可能有抗衰老作用,并与普鲁卡因比较,讨论了其降低LPO的可能途径。Before and after feeding the medicine, Plasma Lipid Peroxide (LPO) level and erythrocyte membrane Na+-K+-ATPase activity are determinted in 9 rabbits among that five are 2-2.5 years old and four are 6 - 8 months old. They are fed with 2 % 654-2 solution 1ml (20mg) every ayd for fourty three days. It is effect that plasma LPO level lower 0.827± 1.048 nmol/ml (P<0.05) but erythrocyte membrane Na+-K+-ATPase activity rise 0.056 ±0.074μmol Pi/mg Pro/hr (P<0.05) in where age is don't distinguished. It 5s considered that 654-2 possibly has anti-senescence effect and it is discussed that the principle of anti-senescence effect of 654-2 is defer from that of procaine.

关 键 词：抗衰老药 NA-K-ATPASE 过氧化脂质 

分 类 号：R977.9[医药卫生—药品]