伊维菌素长效注射液对小鼠的急性毒性试验  

Study on the Acute Toxicity Test of Ivermectin Injection in Mice

作　　者：弓广智 张海亮[2] 高娟 任云利 周洋[2] 李引乾[2] 

机构地区：[1]乾县动物疫病预防控制中心．陕西乾县713300 [2]西北农林科技大学动物医学院,陕西杨陵712100 [3]西安市动物疫病预防控制中心,陕西西安710068

出　　处：《动物医学进展》2008年第12期41-42,共2页Progress In Veterinary Medicine

摘　　要：为考察伊维菌素长效注射液的急性毒性,用简化寇氏法对小鼠的LD50进行了测定。将伊维菌素长效注射液以1∶0.7的组间剂量给试验小鼠一次皮下注射,连续观察7 d。结果表明,伊维菌素长效注射液的LD50为257.04 mg/kg,95%可信限范围为192.84 mg/kg^342.61 mg/kg,符合低毒标准,说明该药临床皮下注射使用安全。In order to observe the actue toxicity of long-action Ivermectin injection, modifited Korbor＇ s method was used to study acute toxicity in mice. Mice were injected with different concentrations of longaction ivermectin in a 1 ： 0.7 intergroup doses,and observed for 7 days. The results showed that the LD50 of long-action ivermectin injection was 257. 04 mg/kg, and 95% confidence limit was 192. 84- 342.61 mg/kg. The results confirmed that long-ation ivermectin injection belongs to hypotoxicity and it is safe to inject subcutaneously.

关 键 词：伊维菌素 LD50 小鼠 

分 类 号：S857.116[农业科学—临床兽医学]