血清中CTnⅠ、GH和hs-CRP水平测定在儿科心血管疾病中的临床应用  

Clinical application of cardiovascular disceases in paediatrics by determining serum CTn I,GH and hs-CRP levels

作　　者：薛雪[1] 徐晓[2] 杨永青[2] 

机构地区：[1]江苏省苏州市市立医院东区,215001 [2]苏州市市立医院本部

出　　处：《中国现代医药杂志》2008年第12期12-14,共3页Modern Medicine Journal of China

摘　　要：目的探讨血清CTnⅠ、GH和hs-CRP水平测定在儿科心血管疾病中的临床应用。方法应用化学发光免疫法分析108例心肌炎患儿、56例青紫型心脏病患儿、36例GHD患儿和60例正常健康儿血清中的CTnⅠ水平,RIA测定血清中的GH和hs-CRP水平,并做了相关性分析。结果108例心肌炎患儿血清中的CTnⅠ、GH和hs-CRP分别为0.088±0.028ng/ml,15.63±2.16μg/L和1.35±0.14mmol/L,均较正常健康儿明显增高(P均<0.01);56例青紫型心脏病患儿血清中CTnⅠ为0.016±0.010ng/ml,较正常健康儿无明显差异(P>0.05),血清中GH和hs-CRP分别为10.89±3.14μg/L和1.22±0.13mmol/L,较正常健康儿明显增高(P均<0.01);36例GHD患儿血清中GH明显降低(P<0.05),而血脂分析表明:TC、LDL-C、apoB和TG明显高于正常健康儿(P分别<0.05或<0.01)。结论血清中CTnⅠ、GH和hs-CRP水平测定是诊断心肌炎、青紫型心脏病和GHD的较好方法,并具有观察治疗效果的作用。Objective To study the clinical application of cardiovascular diseases in paediatrics by determining serum CTn I, GH and hs-CRP levels. Methods The CTn I was determined in serum with chemiluminescence and the GH and hs- CRP were determined in serum by RIA in 108 patients with myocarditis,56 patients with Qing-Zi style heart diseases,36 patients with GHD and 60 controls. Results Serum CTn I , GH and hs-CRP levels in the patients with myocarditis were significantly higher than those in controls （P〈0.01）.Serum CTn I level in the patients with Qing-Zi style heart diseases was no different than those in controls（P〉0.05）, but serum GH and hs-CRP levels were significantly higher（P〈0.01）.Sernm GH levels in the patients with GHD was significantly lower than those in controls （P〈0.05）,but serum TC,LDL-C,apoB and TG levels were significantly higher （P〈0.05or〈0.01）. Conclusion Determining of serum CTn I ,GH and hs-CRP levels is a good markers in diagnosis and outcome prediction for cardiovascular diseases in paediatrics.

关 键 词：儿科学 血管疾病 CTnⅠ GH HS-CRP 

分 类 号：R725.4[医药卫生—儿科] R446.6[医药卫生—临床医学]