低体重儿童血中增食欲素A水平与能量摄入的相关性探讨  

Plasma orexin A levels and the correlation between orexin A and caloric intake in underweight children

作　　者：吴华[1] 李向荣[1] 杨海妹[1] 龙瑜[1] 向开富[1] 

机构地区：[1]南方医科大学附属深圳宝安医院,广东深圳518101

出　　处：《中国儿童保健杂志》2008年第6期639-640,643,共3页Chinese Journal of Child Health Care

基　　金：深圳市科技计划基金资助项目(2005147)

摘　　要：【目的】探讨低体重儿童血中增食欲素A水平的改变及其与能量摄入的相关性。【方法】检测33例低体重儿童的外周血增食欲素A水平、能量摄入,并与33例性别、年龄匹配的健康儿童比较,同时分析血增食欲素A水平与能量摄入的相关性。【结果】①低体重儿童血增食欲素A水平显著高于对照组(F=5.151,P=0.017),而且未发现性别对增食欲素A水平的影响存在交互作用(F=0.773,P=0.508);②低体重儿童血增食欲素A水平与总能量摄入存在着正相关性(r=0.503,P=0.007),与脂肪和蛋白质摄入量均存在着正相关性(P<0.05),与碳水化合物摄入量存在负相关性(r=-0.332,P=0.022);③对照组儿童血增食欲素A水平与总的能量摄入存在着正相关性(r=0.511,P=0.009),与脂肪摄入量、蛋白质摄入量和碳水化合物摄入量均存在正相关性(P<0.015)。【结论】增食欲素A参与了低体重儿童的能量代谢,增食欲素A与能量摄入存在密切的相互作用,而且在不同的营养状态下这一作用不同。[Objective] To analyze the correlation between plasma orexin A levels and Caloric intake in underweight children. [Method] Fasting plasma orexin A concentrations, caloric intake were measured in 33 underweight children and 33 healthy control children. [Results] （1）The plasma orexin A level in underweight children were significantly higher than those in controls （F= 5. 151,P = 0. 017）. （2）In underweight children, there were positive correlation between plasma orexin A levels and total calorie intake（ r = 0. 503, P = 0. 007 ）, fat intake （r = 0. 359, P = 0. 008 ） and protein intake （ r = 0. 381 ,P= 0. 026）, and there were negative correlation between plasma orexin A levels and carbohydrate（r=-0. 332, P= 0. 022）. （3）In control group, there were positive correlation between plasma orexin A levels and total caloric intake（r= 0. 511 ,P=0. 009） ,fat intake（r=0. 411 ,P=0. 007）, protein intake（r= 0. 325 ,P=0. 021 ）, and carbohydrate（r= 0. 383 ,P =0. 015）. [Conclusion] Orexin A may be involved in regulation of energy metabolism in underweight children,and the interaction between orexin A and caloric intake might be different in different nutritional status in children.

关 键 词：增食欲素A 营养不良 儿童 能量摄入 

分 类 号：R723.1[医药卫生—儿科]