新生儿肺炎与血浆纤维蛋白原相关性研究  

Relationship between neonatal pneumonia and plasma fibrinogen

作　　者：李丽红[1] 孙利炜[1] 刘愉[1] 李晓春[1] 

机构地区：[1]吉林省长春市儿童医院,吉林长春130061

出　　处：《临床儿科杂志》2008年第12期1056-1059,共4页Journal of Clinical Pediatrics

基　　金：吉林省长春市科技局基金项目(No.05SF05-B);长春市科技合作项目(No.2005178)

摘　　要：目的探讨新生儿肺炎发生、发展与β纤维蛋白原-455A/G基因多态性和血浆纤维蛋白(FG)水平的关系。方法选择2005年1月-2007年4月住院的新生儿肺炎患儿156例,其中男94例,女62例;年龄20h～30d。采用PCR酶谱法和Clauss凝固法测定β纤维蛋白原-455A/G基因多态性和FG水平,并与门诊体检健康新生儿45例进行对照。结果新生儿肺炎组β纤维蛋白原-455A/GAA型基因频率及A等位基因频率均较对照组有显著增高;新生儿肺炎组FG水平(467.53±27.50)较对照组高;新生儿肺炎患儿中出现合并症者β纤维蛋白原-455A/GAA型基因频率明显增高;新生儿肺炎的AA型OR为11.39,GA型OR为14.46,GG型OR为9.56;A等位基因OR为6.87,G等位基因OR为0.15。β纤维蛋白原-455A/G不同基因型FG水平差异有统计学意义。AA型最高,GA型次之,GG型最低。结论新生儿肺炎的发生发展与β纤维蛋白原-455A/G基因多态性相关;β纤维蛋白原-455A/G不同基因型FG水平不同;FG可能参与了新生儿肺炎的形成。Objectives To investigate the relationship between the development and progression of pneumonia in newborn and the gene polymorphism of fibrinogen β-455A/G, and the level of plasma fibrinogen （FG）. Methods One hundred and fifty-six newborns with pneumonia （94 male and 62 female, aged 20 hours to 30 days after birth） hospitalized in Changchun Children＇s Hospital from January 2005 to April 2007 were enrolled in the study. Polymorphism of gene fibrinogen β-455A/G and level of FG were evaluated with PCR zymography and the method of Clauss solidificaion. Results AA gene frequency and A allele frequency in pneumonia group was much higher than that in the control. The level of FG （467.53 ± 27.50） was higher in pneumonia group than that in the control. AA gene frequency of gene fibrinogen β- 455A/G increased markedly in newborns with pneumonia and other complications. Odds ratio （OR） of newborns with AA genotype, AG genotype, GG genotype, allele A, allele G were 11.39, 14.46, 9.56, 6.87, 0.15, respectively. Levels of FG in patients with different β-455A/G genotypes were different, FG was highest in AA genotype, second in GA genotype, and lowest in GG genotype. The difference of FG level between patients with GG and GA genotypes, as well as between patients with AG and AA genotypes were significant. Conclusions Development and progression of pneumonia in newborns were associated with polymorphism of fibrinogen β-455A/G. Newborns with different genotypes had different levels of FG, which might be involved in the development of neonatal pneumonia.

关 键 词：新生儿 肺炎 纤维蛋白原 基因多态性 

分 类 号：R722.1[医药卫生—儿科]