极端嗜热古菌的热休克蛋白  

Heat Shock Proteins of the Hyperthermophilic Archaea

作　　者：陈华友[1,2] 张春霞[1] 马晓珂[1] 张毅[2] 

机构地区：[1]江苏大学生命科学研究院,镇江212013 [2]中国科学院上海生命科学研究院,上海200233

出　　处：《生物工程学报》2008年第12期2011-2021,共11页Chinese Journal of Biotechnology

基　　金：国家重点基础研究发展计划项目(No.2004CB719606);江苏大学校基金项目(No.08jdg011)资助~~

摘　　要：随着生物工程产业对于耐高温酶和菌体的需求,极端嗜热古菌热休克蛋白(Heatshock proteins,HSPs)的研究更受重视,其热休克蛋白体系非常简洁,不含HSP100s和HSP90s,就是HSP70(DnaK)、HSP40(DnaJ)和GrpE等嗜温古菌可能含有的在极端嗜热古菌中几乎不含有,即仅包括HSP60、sHSP、prefoldin和AAA+蛋白4大类,因此对其结构、功能和作用机制的研究在理论和实践上都特别有意义。系统地介绍了这4大类组分的结构、功能、作用机制和协同作用的研究进展,论述了极端嗜热古菌热休克蛋白的系列研究难点和困惑,展望了进一步的研究方向和重点。As thermostable enzymes and organisms are much more needed, researches on heat shock proteins（HSPs） of hyperthermophilic archaea have drawn more concerns. HSPs from hyperthermophilic archaea are concise only with HSP60, sHSP, prefoldin and AAA＋proteins, but without HSP100s, HSP90s, HSP70 （DnaK）, HSP40 （DnaJ） and GrpE which are common in mesophilic or thermophilic archaea. Accordingly, studies on the structure, function and operation mechanism of these four groups are much more important and meaningful. This review focuses on the recent progress in the researchs on the structure, function, operation mechanism and cooperation of the HSPs from hyperthermophilic archaea. The problems and obfuscations in these HSPs are analyzed, and farther research direction and key points are put out.

关 键 词：热休克蛋白 极端嗜热古菌 协同作用 原始热聚体 

分 类 号：Q93[生物学—微生物学]