PPAR-α与动脉粥样硬化关系的研究进展  

Relationship between peroxisome proliferators-activated receptor and atherosclerosis

作　　者：杜永才[1] 

机构地区：[1]海南省农垦三亚医院,海南三亚572000

出　　处：《中国热带医学》2009年第1期175-177,179,共4页China Tropical Medicine

摘　　要：自20世纪80年代以来,人们认识到动脉粥样硬化的病理学本质是血管壁对各种慢性损伤所作出的一种炎症反应.过氧化物酶体增殖激活受体-α(Peroxisome proliferators-activated receptorα,PPAR-α)是一种核受体,通过与其天源配体如脂肪酸以及人工合成配体如贝特类药物等结合,发挥调节脂质代谢、维持血糖稳定、增强组织对胰岛素的敏感性等作用,此外近来还发现PPAR-α对动脉粥样硬化的不同阶段均有作用,不但能阻止动脉粥样硬化的发生、发展,还能稳定粥样硬化斑块,甚至能不同程度逆转动脉粥样硬化斑块的发展,防止急性心血管事件的发生。本文就近年来关于动脉粥样硬化与PPAR-α关系的研究进展作一简要的回顾.The pathological essence of atherosclerosis is the chronic inflammation of the vascular intima to sustained injury. Peroxisome proliferators-activated receptorot （PPAR-α）is a nuclear receptor activated by natural ligands such as fatty acids as well as by synthetic ligands such as fibrates. PPARct regulates the lipids metabolism,glucose hemeostasis and insulin sensitivity.Furthermore,the recent research indicated that it can also attenuate the initiation and progression of Atherosclerosis, stabilize the atheroplague,even reverse the atherosclerotic lesion,prevent the acute cardiovascular accidents. this article give us a brief review about the relationship between PPAR-α and atherosclerosis.

关 键 词：过氧化物酶体增殖激活受体-α 动脉粥样硬化 研究进展 

分 类 号：R543.5[医药卫生—心血管疾病]