PARP的生物学与病理学功能  

Biological and Pathological Functions of PARPs

作　　者：于孟斌[1,2] 杨予涛[1] 周晓巍[1] 黄培堂[1] 

机构地区：[1]军事医学科学院生物工程研究所,北京100071 [2]防化指挥工程学院生物防护教研室,北京102205

出　　处：《中国生物化学与分子生物学报》2008年第12期1097-1102,共6页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家科技支撑计划(No.2006BAD06A01)~~

摘　　要：PARP是真核细胞内具有多聚腺苷酸二磷酸核糖基(PAR)催化活性的蛋白酶,目前发现18个具有该活性的蛋白.多聚腺苷酸二磷酸核糖基化反应是细胞内进行的翻译后修饰,该修饰作用于许多蛋白,涉及到染色体的稳定,DNA损伤修复,基因转录,细胞的增长,死亡和凋亡等方面.在生理病理方面与炎症,肿瘤,衰老等疾病相关联.本文针对以上方面进行了总结和讨论.Poly（ADP-ribosyl）ation is a post-translational modification of proteins in eukaryotic cells catalyzed by a family of ADP-ribosyl transferases, termed as poly （ADP-ribose） polymerases （PARPs）. The PARP family currently has at least 18 members, and their catalytic domains share a substantial homology with that of the founding member, PARP1. The metabolism of poly （ADP-ribose） involved in a variety of biological processes, including the maintenance of genome stability, DNA repair, transcriptional regulations, cell proliferation, cell death and apoptosis. Poly（ADP-ribosyl）ation is also related to inflammation, cancers and ageing. An overview of PARPs and their functions will be discussed in this review.

关 键 词：多聚腺苷酸二磷酸核糖聚合酶 DNA修复 转录调控 衰老 肿瘤 凋亡 

分 类 号：Q291[生物学—细胞生物学]