萜烯类经皮渗透促进剂的研究与应用进展  

Development and evaluation of terpene penetration enhancers

作　　者：华南[1,2] 刘卫[1] 郭瑞臣[3] 

机构地区：[1]解放军第八十八医院,山东泰安271000 [2]山东大学药学院,山东济南250012 [3]山东大学齐鲁医院临床药理研究所,山东济南250012

出　　处：《中国中药杂志》2008年第24期2875-2882,共8页China Journal of Chinese Materia Medica

摘　　要：透皮给药系统可有效避免肝脏首过效应及胃肠道降解,调控释药速率和血药浓度,降低不良反应及用药频率,提高患者顺应性。但角质层的屏障作用和药物的低渗透量,使其应用受到限制。萜烯类经皮渗透促进剂具有毒性低,促透能力强,可改善皮肤通透性,对亲水、亲脂药物均有促渗作用,低浓度高促透性的特点,在透皮给药系统中日益发挥着重要作用,显示出良好的应用前景。对其来源、分类、促透机制、实际应用、选择评价及应用前景进行综述。Major advantages of transdermal drag delivery system （TDDS） include avoiding of drug degradation in hepatic and gastrointestinal, predetermining release rate and blood drug level, reducing administration frequency and adverse reactions, and increasing patient compliance. But its application was limited by stratum comeum barrier and low skin permeability of drugs. Terpene penetration enhancers are low toxic and can improve the skin permeability and enhance the permeating veloe both of hydrophilie and lipophilic drugs. Terpenes can also significantly enhance the cumulative release amount of drug at its low concentration comparing with other synthetic penetration enhancers, and play an important role in the TDDS. This review presented the source, classification, mechanism and applications of terpenes, combined use with other enhencers and methods. Optimization, evaluation and prospective applications of terpene penetration enhancers were also discussed.

关 键 词：透皮给药系统 萜烯 经皮渗透促进剂 促透剂协同联用 

分 类 号：R94[医药卫生—药剂学]