间质性肺疾病患者肺泡上皮通透性研究  

Study on Lung Epithelial Permeability in Patients with Interstitial Lung Disease

作　　者：李尔然[1,2,3,4] 李亚明[1,2,3,4] 王秋月[1,2,3,4] 罗锡圭 刘又宁[1,2,3,4] 田嘉禾 于润江 

机构地区：[1]中国医科大学第一临床学院呼吸疾病研究所 [2]中国医科大学第一临床学院核医学科 [3]解放军总医院呼吸科 [4]解放军总医院核医学科

出　　处：《中国医学影像学杂志》1998年第1期37-39,共3页Chinese Journal of Medical Imaging

摘　　要：目的：观察ＩＬＤ患者ＬＥＰ的改变及糖皮质类固醇对ＬＥＰ的影响。材料和方法：１２例临床或病理诊断为ＩＬＤ患者。１０名健康人作对照组。采用喷气雾化器吸入９９ｍＴｃＤＴＰＡ气溶胶测定ＬＥＰ。结果：ＩＬＤ患者左肺、左肺上野、左肺中野、右肺、右肺中野的ＬＥＰ显著升高。左肺上野的Ｔ１／２与ＤＬＣＯ、ＤＬＣＯ％及ＰａＯ２呈正相关。结论：（１）临床观察ＩＬＤ患者的ＬＥＰ，尤应注意肺中野；（２）ＬＥＰ与ＤＬＣＯ及ＰａＯ２存在较好的一致性；（３）类固醇并不能改善ＩＬＤ不可逆病变的ＬＥＰ。Purpose: To investigate changes of LEP and effects of GC glucocorticosteroid on LEP in patients with ILD. Materials and Methods: Twelve patients with ILD diagnosed by clincial and pathologic evidence were studied. Control group included 10 healthy women. LEP was measured after inhalation of 99m Tc DTPA aerosol. Results: LEP of five ROI (left lung, left middle lung, left upper lung, right lung, right middle lung) was increased in patients with ILD. LEP of left upper lung had a positive correlation with DLco, DLco% and PaO 2. Conclusions: (1) LEP of middle fields of lungs should be noted particularly in patients with ILD. (2) There exists good correlations among LEP, DLco, and PaO 2. 3. GC could not improve LEP once an irreversible injury had been induced.

关 键 词：间质性肺疾病 肺泡上皮通透性 ^99MTC-DTPA 

分 类 号：R563[医药卫生—呼吸系统] R817.4[医药卫生—内科学]