甲基汞对大鼠小脑的脂质过氧化作用  

Effect of Methylmercury on the Lipid Peroxidation in the Cerebellum of Rats

作　　者：安社娟[1] 陈学敏[1] 杨克敌[1] 杨成峰[1] 谢虹[1] 

机构地区：[1]同济医科大学环境卫生学教研室

出　　处：《环境与健康杂志》1998年第1期5-6,共2页Journal of Environment and Health

基　　金：国家自然科学基金

摘　　要：研究了氯化甲基汞（ＭｅＨｇＣｌ）经口染毒不同剂量及不同时间对大鼠小脑中脂质过氧化产物（ＬＰＯ）及还原型谷胱甘肽（ＧＳＨ）的影响。小脑中ＬＰＯ的含量随着染毒剂量的增加和染毒时间的延长而升高，且有剂量－效应关系和时间－效应关系；ＧＳＨ含量除２．５ｍｇ／ｋｇ剂量组外，其它各组随着染毒剂量的增加和染毒时间的延长而降低，亦有剂量－效应关系和时间－效应关系。本研究提示：ＭｅＨｇ可诱发大鼠小脑的脂质过氧化作用。Effects of methylmercury chloride in different doses and periods in lipid peroxidation (LPO) and glutathione(GSH) in the cerebellum of rats were studied respectively.The level of LPO was significantly increased in a doseand timedependent mannerThe content of GSH was significantly reduced in a doseand timeependent fashion except in the 25mg/kg dosed group.The present study indicated that methylmercury could induce lipid peroxidation in the cerebellum of rats.

关 键 词：甲基汞 脂质过氧化 谷胱甘肽 小脑 汞中毒 

分 类 号：R135.13[医药卫生—劳动卫生]