山楂叶总黄酮防治大鼠胰岛素抵抗及脂肪肝的实验研究  

Empirical study of flavone from hawthorn biloba in preventing and treating insulin resistance and fatty liver in rats

作　　者：刘江[1] 童智[1] 张再超[1] 翁宇静[1] 叶希韵[1] 

机构地区：[1]华东师范大学生命科学学院,上海200062

出　　处：《华东师范大学学报（自然科学版）》2008年第6期127-132,共6页Journal of East China Normal University(Natural Science)

摘　　要：观察山楂叶总黄酮(FHB)对胰岛素抵抗大鼠高血脂、氧化损伤及脂肪肝的防治作用,并对山楂叶总黄酮增强胰岛素敏感性和防治脂肪肝的作用机理进行初步探讨.高糖高脂饲料建立胰岛素抵抗大鼠模型,分为正常组、模型组、FHB组和阳性药物对照文迪雅组.12周末观察FHB对血清血糖、血脂、血清胰岛素含量、脂质过氧化和肝功能等的影响.结果表明,FHB组和模型组比较可以显著降低胰岛素抵抗大鼠血清FFA和TG水平,提高HDL-C水平;降低ALT和AST活性,降低肝指数,防止肝脏组织脂肪性病变,同时,明显提高总抗氧化能力和肝脏组织中SOD活性,降低MDA含量.由此得出结论,FHB对胰岛素抵抗大鼠高血脂和氧化损伤起到了良好的防治作用,能够改善病鼠胰岛素抵抗状态,增强其胰岛素敏感性,并具有良好的防治脂肪肝作用.This paper investigated the preventive effects of flavone from hawthorn biloba （FHB） in insulin resistant rats with hyperlipemia, oxidation and fatty liver, and explored the possible mechanisms on enhancing insulin sensitivity and protecting fatty liver. High fat-sugar diet was fed in rats to produce insulin resistance model. Forty male SD rats were classified into 4 groups randomly： the normal group, the control group, the FHB group and the rosiglitazone group. Then the FHB and the rosiglitazone group were administered for 12 weeks, and blood of the rats was sampled to determin the levels of FFA, TC, TG, HDL-C and T-AOC, and the activities of AST and ALT. As a result, FHB could decrease the levels of FFA and TG, and increase the level of HDL-C, while reduce the activities of ALT, AST and liver index, and reduce the damaged degree of the liver tissue steatosis significantly. FHB also could enhance the activities of SOD and reduce the amount of MDA significantly. Meanwhile, FHB could conspicuously improve the insulin resistance and sensitivity. This work highlights the fact that FHB can regulate actions on hyperlipemia, blood glucose, insulin and oxidation, and improve liver functions of insulin resistant rats induced by high-fat-sugar diet. In addition, FHB can enhance insulin sensitivity, antagonize IR and prevent fatty liver in rats.

关 键 词：山楂叶总黄酮 胰岛素抵抗 血脂 游离脂肪酸 脂肪肝 

分 类 号：R285.5[医药卫生—中药学]