大黄素对牙周炎大鼠牙龈组织中IL-6的影响  

Influence of emodin upon interleukin-6 of experimental periodontitis rat gum tissue

作　　者：孙庆顺[1] 刘亚梅[1] 李维善[1] 邵必波[1] 李东[1] 

机构地区：[1]佳木斯大学附属口腔医院牙周黏膜病科,黑龙江佳木斯154002

出　　处：《黑龙江医药科学》2008年第6期39-40,共2页Heilongjiang Medicine and Pharmacy

摘　　要：目的:观察中药大黄素对牙周炎大鼠牙龈组织IL-6的影响,探讨大黄素治疗牙周炎的可能机理。方法:健康雄性4月龄Wistar大鼠40只建立牙周炎模型。建模后将大鼠随机分为4组,每组10只:P组模型对照组;P 1组小剂量大黄素(80m g/kg)治疗组;P 2组大剂量(100m g/kg)大黄素治疗组;P 3组替硝唑(400m g/kg)治疗组。分别于用药前和用药15d处死取材,免疫组化法观察炎症局部IL-6的变化。结果:两种剂量的大黄素治疗组炎症局部IL-6的表达均低于模型对照组(P<0.05),牙周炎症也较模型对照组轻。大剂量大黄素组与替硝唑组对比牙龈组织IL-6改善无显著性差异(P>0.05)。结论:大黄素可通过下调炎症局部IL-6改善牙周状况。Objective：To observe the effects of emodin？on interleukin-6 of experimental pertodontitts rat gum tissue and approach the possibal mechanism of the treatment of periodontitis. Methods：We used 40 4- month Wistar rats to form experimental periodontitis models,then divided them into four groups at random： Group P- the model cor, trol group ;Group Pl-the treatment group of the lower dosage of emodin（80mg/kg） ; Group P2- the treatment group of the high dosage of emodin （100mg/kg）;Group P3- the treatment group of tinidazole （400mg/kg）. The rats were killed respectively before medication and at 15 days after medication to observe the IL-6 change of the inflammation tissure by immunohistoehemistry. Results.The IL--6 levels in emodin treatment groups were lower （P 〈 0. 05）. At the same time, the general conditions and pathological changes were better in treatment groups than those in the model group. In addition,there was no difference be- tween the control group and the high dosage group odont condition？by lowering the IL--6 level in the （P 〉 0.05） . Conclusion：The emodin can improve the periperipheral tissue of the experimental periodontitis model.

关 键 词：牙周炎 白细胞介素6 大黄素 

分 类 号：R285[医药卫生—中药学]